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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 651 - 661 (11page)
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초록· 키워드
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Targeting the pathogen viability using drugs is associated with development of drug resistance due to selective pressure. Hence, there is an increased interest in developing agents that target bacterial virulence. In this study, the inhibitory effect of ciclopirox, an antifungal agent with iron chelation potential, on the microbial virulence factors was evaluated in 26 clinical MDR Pseudomonas aeruginosa isolates collected from Alexandria Main University Hospital, a tertiary hospital in Egypt. Treatment with 9 μg/ml ciclopirox inhibited the hemolytic activity in 70% isolates, reduced pyocyanin production, decreased protease secretion in 46% isolates, lowered twitching and swarming motility, and decreased biofilm formation by 1.5- to 4.5-fold. The quantitative real-time PCR analysis revealed that treatment with ciclopirox downregulated the expression levels of alkaline protease (aprA) and pyocyanin (phzA1). Ciclopirox is used to treat hematological malignancies and the systemic administration of ciclopirox is reported to have adequate oral absorption with a satisfactory drug safety profile. It is important to calculate the appropriate clinical dose and therapeutic index to reposition ciclopirox from a topical antifungal agent to a promising virulence- modifying agent agent against P. aeruginosa, a problematic Gram-negative pathogen.
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참고문헌 (53)
참고문헌 신청
Heras B / 2014 / Targeting virulence not viability in the search for future antibacterials / Br. J. Clin. Pharmacol 79:208~215
Carlson-Banning KM / 2013 / Toward repurposing ciclopirox as an antibiotic against drug-resistant Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae / PLoS One 8:e69646
Sonthalia S / 2018 / Topical ciclopirox - recalling a for gotten ally in the fight against cutaneous mycoses / EC Microbiology 14:515~534
Alnour TMS / 2017 / Multidrug resistant Pseudomonas (P) aeruginosa: medical impact, pathogenicity, resistance mechanisms and epidemiology / JSM Microbiology 5:1046
Strateva T / 2011 / Contribution of an arsenal of virulence factors to pathogenesis of Pseudomonas aeruginosa infections / Ann. Microbiol 61:717~732
Carlson-Banning KM / 2013 / Toward repurposing ciclopirox as an antibiotic against drug-resistant Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae / PLoS One 8:e69646
Sonthalia S / 2018 / Topical ciclopirox - recalling a for gotten ally in the fight against cutaneous mycoses / EC Microbiology 14:515~534
Alnour TMS / 2017 / Multidrug resistant Pseudomonas (P) aeruginosa: medical impact, pathogenicity, resistance mechanisms and epidemiology / JSM Microbiology 5:1046
Strateva T / 2011 / Contribution of an arsenal of virulence factors to pathogenesis of Pseudomonas aeruginosa infections / Ann. Microbiol 61:717~732
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