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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 551 - 571 (21page)
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Nuclear receptor-related 1 (Nurr1) protein has been identified as an obligatory transcription factor in midbrain dopaminergic neurogenesis, but the global set of human NURR1 target genes remains unexplored. Here, we identified direct gene targets of NURR1 by analyzing genome-wide differential expression of NURR1 together with NURR1 consensus sites in three human neural stem cell (hNSC) lines. Microarray data were validated by quantitative PCR in hNSCs and mouse embryonic brains and through comparison to published human data, including genome-wide association study hits and the BioGPS gene expression atlas. Our analysis identified ~40 NURR1 direct target genes, many of them involved in essential protein modules such as synapse formation, neuronal cell migration during brain development, and cell cycle progression and DNA replication. Specifically, expression of genes related to synapse formation and neuronal cell migration correlated tightly with NURR1 expression, whereas cell cycle progression correlated negatively with it, precisely recapitulating midbrain dopaminergic development. Overall, this systematic examination of NURR1-controlled regulatory networks provides important insights into this protein’s biological functions in dopamine-based neurogenesis.
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참고문헌 (77)
참고문헌 신청
Andersson, E. R. / 2013 / Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells / Proc. Natl. Acad. Sci. U. S. A 110:E602~E610
Arama, J. / 2012 / Bmcc1s, a novel brain-isoform of Bmcc1, affects cell morphology by regulating MAP6/STOP functions / PLoS One 7:e35488
Bernard, A. / 2012 / Transcriptional architecture of the primate neocortex / Neuron 73:1083~1099
Bharathan, N. K. / 2019 / Desmoplakin is required for epidermal integrity and morphogenesis in the Xenopus laevis embryo / Dev. Biol 450:115~131
Blakely, B. D. / 2011 / Wnt5a regulates midbrain dopaminergic axon growth and guidance / PLoS One 6:e18373
Arama, J. / 2012 / Bmcc1s, a novel brain-isoform of Bmcc1, affects cell morphology by regulating MAP6/STOP functions / PLoS One 7:e35488
Bernard, A. / 2012 / Transcriptional architecture of the primate neocortex / Neuron 73:1083~1099
Bharathan, N. K. / 2019 / Desmoplakin is required for epidermal integrity and morphogenesis in the Xenopus laevis embryo / Dev. Biol 450:115~131
Blakely, B. D. / 2011 / Wnt5a regulates midbrain dopaminergic axon growth and guidance / PLoS One 6:e18373
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