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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 317 - 322 (6page)
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초록· 키워드
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Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases. NAFLD can further progress to irreversible liver failure such as non-alcoholic steatohepatitis (NASH) fibrosis and cirrhosis. However, specific regulator of NASHfibrosis has yet to be established. Here, we found that glutathione peroxidase 7 (GPx7) was markedly expressed in NASH fibrosis. Although GPx7 is an antioxidant enzyme protecting other organs, whether GPx7 plays a role in NASH fibrosis has yet to be studied. We found that knockdown of GPx7 in transforming growth factor- (TGF-) and free fatty acids (FFA)- treated LX-2 cells elevated the expression of pro-fibrotic and pro-inflammatory genes and collagen synthesis. Consistently, GPx7 overexpression in LX-2 cells led to the suppression of ROS production and reduced the expression of pro-fibrotic and pro-inflammatory genes. Further, NASH fibrosis induced by choline-deficient amino acid defined, high fat diet (CDAHFD) feeding was significantly accelerated by knockdown of GPx7, as evidenced by up-regulated liver fibrosis and inflammation compared with CDAHFD control mice. Collectively, these results suggest that GPx7 might be a novel therapeutic target to prevent the progression and development of NAFLD.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Buzzetti E / 2016 / The multiple-hit pathogenesis of non-alcoholic fatty liver disease(NAFLD) / Metabolism 65:1038~1048
Hardy T / 2016 / Nonalcoholic Fatty Liver Disease : Pathogenesis and Disease Spectrum / Annu Rev Pathol 11:451~496
Cohen JC / 2011 / Human fatty liver disease : old questions and new insights / Science 332:1519~1523
Szczepaniak LS / 2005 / Magnetic resonance spectroscopy to measure hepatic triglyceride content : prevalence of hepatic steatosis in the general population / Am J Physiol Endocrinol Metab 288:E462~468
Promrat K / 2010 / Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis / Hepatology 51:121~129
Hardy T / 2016 / Nonalcoholic Fatty Liver Disease : Pathogenesis and Disease Spectrum / Annu Rev Pathol 11:451~496
Cohen JC / 2011 / Human fatty liver disease : old questions and new insights / Science 332:1519~1523
Szczepaniak LS / 2005 / Magnetic resonance spectroscopy to measure hepatic triglyceride content : prevalence of hepatic steatosis in the general population / Am J Physiol Endocrinol Metab 288:E462~468
Promrat K / 2010 / Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis / Hepatology 51:121~129
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