지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 6 (6page)
이용수
초록· 키워드
오류제보하기
Sterol regulatory element binding protein (SREBP) cleavage activating protein (SCAP) is a key regulator of SREBP maturation. SCAP induces translocation of SREBP from the endoplasmic reticulum to the Golgi apparatus, allowing it to regulate cellular triglyceride and cholesterol levels. Previous studies have shown that suppression of SREBP activation in SCAP conditional knockout mice reduced the accumulation of intracellular triglycerides, which eventually causes the development of metabolic diseases such as atherosclerosis, diabetes, hepatic steatosis, and insulin resistance. However, despite the significance of SCAP as a regulator of SREBP, its function has not been thoroughly discussed. In this review, we have summarized the function of SCAP and its regulatory proteins. Furthermore, we discuss recent studies regarding SCAP as a possible therapeutic target for hypertriglyceridemia and hyperlipidemia.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Scaps를 이용한 물성변수에 따른 태양전지 특성 연구
한국태양에너지학회 학술대회논문집
2022 .04
-
Investigation of Eco-friendly Perovskite Solar Cell Employing Niobium Pentoxide as Electron Transport Material using SCAPS-1D
Transactions on Electrical and Electronic Materials
2024 .06
-
SCAPS-1D 시뮬레이션을 이용한 n-i-p 구조 페로브스카이트 태양전지의 열적 열화 원인 분석
Current Photovoltaic Research
2022 .03
-
Transplantation of Neural Progenitor Cells Derived from Stem Cells from Apical Papilla Through Small-Molecule Induction in a Rat Model of Sciatic Nerve Injury
조직공학과 재생의학
2024 .08
-
Efficiency Enhancement of Transition Metal Dichalcogenide Based Solar Cells
Transactions on Electrical and Electronic Materials
2021 .10
-
Loss of SREBP-1c ameliorates iron-induced liver fibrosis by decreasing lipocalin-2
Experimental and Molecular Medicine
2024 .04
-
Investigating Effect of CdS Buff er Layer on the Performance of Cu 2 ZnSnS 4 Based Solar Cells Using SCAPS-1D
Transactions on Electrical and Electronic Materials
2021 .01
-
The mechanisms of the inhibitory effects of green tea seed saponins on the accumulation of adipose tissues, control of obesity and its complications
한국생물공학회 학술대회
2016 .10
-
Gα12/13 signaling in metabolic diseases
Experimental and Molecular Medicine
2020 .01
-
Design and Numerical Investigation of CsSn0.5 Ge0.5 I3 Perovskite Photodetector with Optimized Performances
Transactions on Electrical and Electronic Materials
2024 .02
-
Numerical Studies of Optimising Various Buffer Layers to Enhance the Performance of Tin Sulfi de (SnS)-Based Solar Cells
Transactions on Electrical and Electronic Materials
2021 .12
-
Ursolic Acid Suppresses Cholesterol Biosynthesis and Exerts Anti-cancer Effects in Hepatocellular Carcinoma Cells
한국생물공학회 학술대회
2020 .10
-
Numerical Modeling and Optimization of ZnO:Al/iZnO/ZnMgO/CZTS Photovoltaic Solar Cell
Transactions on Electrical and Electronic Materials
2021 .10
-
Effect of Mechanical Stimuli on Intracellular Protein Translocation
대한기계학회 춘추학술대회
2022 .11
-
Engineering Bacterial Toxins for Intracellular Delivery of Regulatory Proteins in a Signaling Pathway
한국생물공학회 학술대회
2016 .10
-
The Golgi complex: a hub of the secretory pathway
BMB Reports
2021 .01
-
Antiobesity Effects of Green tea Saponins on Animal Model Feed with Lipid and Carbohydrates Rich Diet
한국생물공학회 학술대회
2016 .04
-
Metabolic and Cellular Engineering Strategies for the Production of Natural Products
한국생물공학회 학술대회
2023 .04
-
Inhibition of Endoplasmic Reticulum Stress-induced Apoptosis by Silkworm Storage Protein 1
한국생물공학회 학술대회
2019 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0