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Hadron therapy, such as carbon and helium ions, is increasingly coming to the fore for thetreatment of cancers. Such hadron therapy has several advantages over conventional radiotherapyusing photons and electrons physically and clinically. These advantages are due to the differentphysical and biological characteristics of heavy ions including high linear energy transfer and Braggpeak, which lead to the reduced exit dose, lower normal tissue complication probability and theincreased relative biological effectiveness (RBE). Despite the promising prospects on the carbonion radiation therapy, it is in dispute with which bio-mathematical models to calculate the carbonion RBE. The two most widely used models are local effect model and microdosimetric kineticmodel, which are actively utilized in Europe and Japan respectively. Such selection on the RBEmodel is a crucial issue in that the dose prescription for planning differs according to the models. Inthis study, we aim to (i) introduce the concept of RBE, (ii) clarify the determinants of RBE, and (iii)compare the existing RBE models for carbon ion therapy.
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참고문헌 (29)
참고문헌 신청
Durante M / 2018 / Heavy charged particles: does improved precision and higher biological effectiveness translate to better outcome in patients? / Semin Radiat Oncol 28:160~167
Karger CP / 2017 / RBE and related modeling in carbon-ion therapy / Phys Med Biol 63:01TR02
Fossati P / 2018 / Radiobiological issues in prospective carbon ion therapy trials / Med Phys 45:e1096~e1110
Loeffler JS / 2013 / Charged particle therapy--optimization, challenges and future directions / Nat Rev Clin Oncol 10:411~424
Wang T / 2014 / The basic structure of heavy-ion tumor therapy facility / Zhongguo Yi Liao Qi Xie Za Zhi 38:427~429
Karger CP / 2017 / RBE and related modeling in carbon-ion therapy / Phys Med Biol 63:01TR02
Fossati P / 2018 / Radiobiological issues in prospective carbon ion therapy trials / Med Phys 45:e1096~e1110
Loeffler JS / 2013 / Charged particle therapy--optimization, challenges and future directions / Nat Rev Clin Oncol 10:411~424
Wang T / 2014 / The basic structure of heavy-ion tumor therapy facility / Zhongguo Yi Liao Qi Xie Za Zhi 38:427~429
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