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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Purpose: With neurodegeneration, the signal intensity of the cerebrospinal fluid (CSF) in the brain increases. The objective of this study was to evaluate chemical exchange saturation transfer (CEST) signals with and without the contribution of CSF signals in elderly human brains using two different 3T magnetic resonance imaging (MRI) sequences Methods: Full CEST signals were acquired in ten subjects (Group I) with a three-dimensional (3D)-segmented gradient-echo echo-planar imaging (EPI) sequence and in ten other subjects (Group II) with a 3D gradient and spin-echo (GRASE) sequence using two different 3T MRI systems. The segmented tissue compartments of gray and white matter were used to mask the CSF signals in the full CEST images. Two sets of magnetization transfer ratio asymmetry (MTRasym) maps were obtained for each offset frequency in each subject with and without masking the CSF signals (masked and unmasked conditions, respectively) and later compared using paired t-tests. Results: The region-of-interest (ROI)-based analyses showed that the MTRasym values for both the 3D-segmented gradient-echo EPI and 3D GRASE sequences were altered under the masked condition compared with the unmasked condition at several ROIs and offset frequencies. Conclusions: Depending on the imaging sequence, the M TRasym values can be overestimated for some areas of the elderly human brain when CSF signals are unmasked. Therefore, it is necessary to develop a method to minimize this overestimation in the case of elderly patients.
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참고문헌 (21)
참고문헌 신청
오장훈 / 2017 / Chemical-Exchange-Saturation-Transfer Magnetic Resonance Imaging to Map Gamma-Aminobutyric Acid, Glutamate, Myoinositol, Glycine, and Asparagine: Phantom Experiments / Journal of the Korean Physical Society 70(5):545~553
Dagher AP / 2000 / Imaging of urea using chemical exchange-dependent saturation transfer at 1.5T / J Magn Reson Imaging 12:745~748
Guivel-Scharen V / 1998 / Detection of proton chemical exchange between metabolites and water in biological tissues / J Magn Reson 133:36~45
Zhou J / 2003 / Amide proton transfer(APT)contrast for imaging of brain tumors / Magn Reson Med 50:1120~1126
van Zijl PC / 2011 / Chemical exchange saturation transfer (CEST): what is in a name and what isn’t? / Magn Reson Med 65:927~948
Dagher AP / 2000 / Imaging of urea using chemical exchange-dependent saturation transfer at 1.5T / J Magn Reson Imaging 12:745~748
Guivel-Scharen V / 1998 / Detection of proton chemical exchange between metabolites and water in biological tissues / J Magn Reson 133:36~45
Zhou J / 2003 / Amide proton transfer(APT)contrast for imaging of brain tumors / Magn Reson Med 50:1120~1126
van Zijl PC / 2011 / Chemical exchange saturation transfer (CEST): what is in a name and what isn’t? / Magn Reson Med 65:927~948
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