지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 123 - 134 (12page)
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초록· 키워드
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Background: The lepidopteran Asiatic corn borer (ACB), Ostrinia furnacalis (Guenee), has caused huge economic losses throughout the Asian-Western Pacific region. Usually, chemical pesticides are used for the control, but excessive use of pesticides has caused great harm. Therefore, the inartificial ecotypic pesticides to ACB are extremely essential. In our previous study, we found that panaxadiol saponins (PDS) can effectively reduce the harm of ACB by causing antifeedant activity. Therefore, it is necessary to reveal the biological molecular changes in ACB and the functionary mechanism of PDS.
Methods: We analyzed the global transcription of ACB with different PDS concentration treatment (5 mg/mL, 10 mg/mL, and 25 mg/mL) by high-throughput sequencing and de novo transcriptome assembly method.
Results: PDS treatment could cause the changes of many gene expressions which regulate its signal pathways. The genes in peroxisome proliferator-activated receptor (PPAR) signaling pathway were significantly downregulated, and then, the downstream fatty acid degradation pathway had also been greatly affected.
Conclusion: Through this experiment, we hypothesized that the occurrence of antifeedant action of ACB is because the PDS brought about the downregulation of FATP and FABP, the key regulators in the PPAR, and the downregulation of FATP and FABP exerts further effects on the expression of SCD-1, ACBP, LPL, SCP-X, and ACO, which leads to the disorder of PPAR signaling pathway and the fatty acid degradation pathway. Not only that, PDS treatment leads to enzyme activity decrease by inhibiting the expression of genes associated with catalytic activity, such as cytochrome P450 and other similar genes.
Methods: We analyzed the global transcription of ACB with different PDS concentration treatment (5 mg/mL, 10 mg/mL, and 25 mg/mL) by high-throughput sequencing and de novo transcriptome assembly method.
Results: PDS treatment could cause the changes of many gene expressions which regulate its signal pathways. The genes in peroxisome proliferator-activated receptor (PPAR) signaling pathway were significantly downregulated, and then, the downstream fatty acid degradation pathway had also been greatly affected.
Conclusion: Through this experiment, we hypothesized that the occurrence of antifeedant action of ACB is because the PDS brought about the downregulation of FATP and FABP, the key regulators in the PPAR, and the downregulation of FATP and FABP exerts further effects on the expression of SCD-1, ACBP, LPL, SCP-X, and ACO, which leads to the disorder of PPAR signaling pathway and the fatty acid degradation pathway. Not only that, PDS treatment leads to enzyme activity decrease by inhibiting the expression of genes associated with catalytic activity, such as cytochrome P450 and other similar genes.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (73)
참고문헌 신청
Nafus DM / 1991 / Review of the biology and control of the Asian corn borer, Ostrinia furnacalis(Lep : Pyralidae) / Trop Pest Manage 37:41~56
He K / 2003 / Evaluation of transgenic Bt corn for resistance to the Asian corn borer(Lepidoptera : Pyralidae) / J Econ Entomol 96:935~940
Zhang T / 2016 / Transcriptome comparison analysis of Ostrinia furnacalis in four developmental stages / Sci Rep 6:e35008
Hernandez M / 2008 / Pesticide abuse in Europe : effects on the Cinereous vulture(Aegypius monachus)population in Spain / Ecotoxicology 17:264~272
lqbal Z / 1997 / Pesticide abuse in Pakistan and associated human health and environmental risks / Pak J Agric Sci 34:4
He K / 2003 / Evaluation of transgenic Bt corn for resistance to the Asian corn borer(Lepidoptera : Pyralidae) / J Econ Entomol 96:935~940
Zhang T / 2016 / Transcriptome comparison analysis of Ostrinia furnacalis in four developmental stages / Sci Rep 6:e35008
Hernandez M / 2008 / Pesticide abuse in Europe : effects on the Cinereous vulture(Aegypius monachus)population in Spain / Ecotoxicology 17:264~272
lqbal Z / 1997 / Pesticide abuse in Pakistan and associated human health and environmental risks / Pak J Agric Sci 34:4
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UCI(KEPA) : I410-ECN-0101-2020-524-000504586