지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.3
- 수록면
- 72 - 77 (6page)
- DOI
- 10.7841/ksbbj.2020.35.1.72
이용수
초록· 키워드
오류제보하기
Obesity is caused by a variety of reasons, such as diet, genetics, and environmental factors. Here the effect of Barley sprout extract on the differentiation of 3T3-L1 and the expression of adipogenesis was studied. MTT assay for cell toxicity was performed and found to be non-toxic at 3T3-L1, with a survival rate of 90% or higher in Barley sprout extract at all concentrations. The results of oil red O assay, after inducing differentiation by treating the fat formation with insulin, dexamethasone, and IBMX powder-inducing substances at 3T3-L1, showed that the Barley sprout extract inhibited fat formation. The results of a triglyceride assay for the determination of quantitative inhibition of fat formation showed 42.2% and 45.7% in Barley sprout extracts of 50% and 70%, respectively. Western blot was performed to identify the proteins involved in fat cell suppression, and it was found that there was a concentration-dependent decrease in C/EBPα, PPARγ, and p-ACC proteins. Thus, Barley sprout ethanol extract regulates the expression of protein involved in inhibiting fat cells, thereby reducing the differentiation of fat cells and triglyceride production and indicating that it is effective against obesity.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHODS
3. RESULTS AND DISCUSSION
4. CONCLUSION
REFERENCES
참고문헌 (25)
참고문헌 신청
Listenberger, L. L. / 2003 / Triglyceride accumulation protects against fatty acidinduced lipotoxicity / Proc Natl Acad Sci U S A 100:3077~3082
Castelli, W. P. / 1986 / The triglyceride issue : a view from Framingham / J Am Heart Assoc 112:432~437
Smith, P. J. / 1988 / Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes / J Biol Chem 263:9402~9408
Sakoda, H. / 2000 / Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction / Diabetes 49:1700~1708
Kanda, K. / 2012 / Nobiletin suppresses adipocyte differentiation of 3T3-L1cells by an insulin and IBMX mixture induction / Biochim Biophys Acta Biomembr 1820:461~468
Castelli, W. P. / 1986 / The triglyceride issue : a view from Framingham / J Am Heart Assoc 112:432~437
Smith, P. J. / 1988 / Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes / J Biol Chem 263:9402~9408
Sakoda, H. / 2000 / Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction / Diabetes 49:1700~1708
Kanda, K. / 2012 / Nobiletin suppresses adipocyte differentiation of 3T3-L1cells by an insulin and IBMX mixture induction / Biochim Biophys Acta Biomembr 1820:461~468
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UCI(KEPA) : I410-ECN-0101-2020-470-000539375