Risk factors affecting postoperative pulmonary function in congenital diaphragmatic hernia

Qianqian Wang; Quanhua Liu; Jingyu Zang; Jun Wang; Jie Chen

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자료유형: 학술저널

저자정보: Qianqian Wang (Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine) Quanhua Liu (Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine) Jingyu Zang (Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine) Jun Wang (Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine) Jie Chen (Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.98 No.4

발행연도: 2020.4

수록면: 206 - 213 (8page)

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Purpose: It is well known that congenital diaphragmatic hernia (CDH) in infants impacts pulmonary function rehabilitation after surgery. However, the risk factors of postoperative pulmonary function are still unclear. In this research, we analyzed the potential risk factors of postoperative pulmonary function in CDH patients in order to improve the clinical management of CDH patients.
Methods: Thirty-three cases CDH infants followed were enrolled from November 2016 to September 2018. Clinical data were reviewed. Tidal breathing pulmonary function testing was performed after surgery. Correlation between pulmonary function and clinical characteristics was evaluated using multivariate analysis of variance.
Results: Pulmonary dysfunction was detected in 87.9% patients (29 of 33). The defect size was found to be significantly larger in patients with obstructed and mixed ventilatory disorders (P = 0.001). Diagnosis of gestational age (GA) was also significantly earlier compared to restrictive ventilatory disorders (P = 0.001). Larger defect size, and earlier prenatal diagnosis of GA were detected in severe obstructive ventilatory disorders (P = 0.007, P = 0.001, retrospectively).
Conclusion: Most patients had various degrees of pulmonary dysfunction after surgery. Patients with larger defect size and earlier diagnosis time might be vulnerable to severe obstructive and mixed ventilatory disorders.

#Airway obstruction #Infant #Tidal volume

참고문헌 (15)

참고문헌 신청

Ameis D / 2017 / Abnormal lung development in congenital diaphragmatic hernia / Semin Pediatr Surg 26:123~128

Panitch HB / 2015 / Lung function over the first 3 years of life in children with congenital diaphragmatic hernia / Pediatr Pulmonol 50:896~907

Spoel M / 2013 / Lung function in young adults with congenital diaphragmatic hernia; a longitudinal evaluation / Pediatr Pulmonol 48:130~137

American Thoracic Society; European Respiratory Society / 2005 / ATS/ERS statement : raised volume forced expirations in infants : guidelines for current practice / Am J Respir Crit Care Med 172:1463~1471

Spoel M / 2012 / Prospective longitudinal evaluation of lung function during the first year of life after repair of congenital diaphragmatic hernia / Pediatr Crit Care Med 13:e133~e139

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