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- 학술저널
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- 2019.12
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Immunosenescence is characterized by a progressive deterioration of the immune system associated with aging. Multiple components of both innate and adaptive immune systems experience aging-related changes, such as alterations in the number of circulating monocytic
and dendritic cells, reduced phagocytic activities of neutrophils, limited diversity in B/T cell repertoire, T cell exhaustion or inflation, and chronic production of inflammatory cytokines known as inflammaging. The elderly are less likely to benefit from vaccinations as preventative measures against infectious diseases due to the inability of the immune system to mount a successful defense. Therefore, aging is thought to decrease the efficacy and effectiveness of vaccines, suggesting aging-associated decline in the immunogenicity induced by vaccination. In this review, we discuss aging-associated changes in the innate and adaptive immunity and the impact of immunosenescence on viral infection and immunity. We further explore recent advances in strategies to enhance the immunogenicity of vaccines in the elderly. Better understanding of the molecular mechanisms underlying immunosenescencerelated immune dysfunction will provide a crucial insight into the development of effective elderly-targeted vaccines and immunotherapies.
and dendritic cells, reduced phagocytic activities of neutrophils, limited diversity in B/T cell repertoire, T cell exhaustion or inflation, and chronic production of inflammatory cytokines known as inflammaging. The elderly are less likely to benefit from vaccinations as preventative measures against infectious diseases due to the inability of the immune system to mount a successful defense. Therefore, aging is thought to decrease the efficacy and effectiveness of vaccines, suggesting aging-associated decline in the immunogenicity induced by vaccination. In this review, we discuss aging-associated changes in the innate and adaptive immunity and the impact of immunosenescence on viral infection and immunity. We further explore recent advances in strategies to enhance the immunogenicity of vaccines in the elderly. Better understanding of the molecular mechanisms underlying immunosenescencerelated immune dysfunction will provide a crucial insight into the development of effective elderly-targeted vaccines and immunotherapies.
목차
ABSTRACT
INTRODUCTION
AGING-ASSOCIATED CHANGES IN INNATE IMMUNE CELLS
AGING-ASSOCIATED CHANGES IN ADAPTIVE IMMUNE CELLS
IMPACT OF AGING ON VIRAL INFECTION AND IMMUNITY
CONCLUSION AND FUTURE PERSPECTIVES
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2020-517-000376125