지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Hypertriglyceridemia is one of the metabolic syndrome that is often observed as a result of lipid abnormalities. It is associated with other lipids, metabolic disorders, cardiovascular disease and liver disease. Korean red ginseng is known to affect obesity, dyslipidemia, liver disease and liver function, but the mechanism of its effect is not clear. This study examined the beneficial effects of hypertriglyceridemia and the mechanism of action of Jinan red ginseng extract (JRG) in hepatoma cells. To measure the levels of triglyceride accumulation, we studied the expression of proteins and mRNAs related to lipidogenesis in hepatoma cells (Huh7 and HepG2). JRG decreases the lipidogenic markers, peroxisome proliferator-activated receptor γ (PPARγ), CCAAT-enhancer-binding proteins α (C/EBPα) and C/EBPβ which are major regulators of triglyceride synthesis in hepatoma cells. We also found that JRG reduced sterol regulatory element binding proteins 1c (SREBP-1c), C/EBPα and C/EBPβ by regulating liver X receptor (LXR) and stearoyl CoA desaturase (SCD) expressions. In addition, the first-limited step of synthesis triglyceride (TG), glycerol-3-phosphate (G3P) is decreased by JRG. These results suggest that the anti-hypertriglyceride effect of JRG in hepatoma cells could be accompanied with the inhibition of lipidogenic transcription factors by regulating LXR and SCD expression.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Conclusion
References
참고문헌 (34)
참고문헌 신청
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Chan L, Yue PY, Mak N, Wong RN. Role of microRNA-214 in ginsenoside- Rg1-induced angiogenesis. Eur. J. Pharm. Sci. 38: 370- 377 (2009)
Chen X, Huang T, Zhang J, Song J, Chen L, Zhu Y. Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1’s attenuation of β-amyloid peptide25-35-induced Tau hyperphosphorylation in cortical neurons. Brain Res. 1200: 99-106 (2008)
Choi JE, Nam KY, Li X, Kim BY, Cho HS, Hwang KB. Changes of chemical compositions and ginsenoside contents of different root parts of ginsengs with processing method. Korean J.Medicinal Crop Sci. 18: 118-125 (2010)
Chu K, Miyazaki M, Man WC, Ntambi JM. Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol. Cell. Biol. 26: 6786-6798 (2006)
Chan L, Yue PY, Mak N, Wong RN. Role of microRNA-214 in ginsenoside- Rg1-induced angiogenesis. Eur. J. Pharm. Sci. 38: 370- 377 (2009)
Chen X, Huang T, Zhang J, Song J, Chen L, Zhu Y. Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1’s attenuation of β-amyloid peptide25-35-induced Tau hyperphosphorylation in cortical neurons. Brain Res. 1200: 99-106 (2008)
Choi JE, Nam KY, Li X, Kim BY, Cho HS, Hwang KB. Changes of chemical compositions and ginsenoside contents of different root parts of ginsengs with processing method. Korean J.Medicinal Crop Sci. 18: 118-125 (2010)
Chu K, Miyazaki M, Man WC, Ntambi JM. Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol. Cell. Biol. 26: 6786-6798 (2006)
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UCI(KEPA) : I410-ECN-0101-2020-594-000118271