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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Rheumatoid arthritis (RA) is a systemic inflammatory disease that manifests as joint damage or athletic disability via sustained inflammation of the synovial membrane. The risk of cardiovascular disease (CVD) is higher in RA patients. This study aimed at evaluating the association between CVD comorbidities and RA by comparing a pharmacotherapy group with a nonpharmacotherapy group. Methods: Patient sample data from the Health Insurance Review and Assessment Service (HIRA-NPS- 2016) were used. Inverse probability of treatment weighting (IPTW) using the propensity score was used to minimize the differences in patient characteristics. Logistic regression analysis was used to evaluate the risk of CVD comorbidities. Results: The analyses included 1,207,213 patients, of which 33,122 (2.8%) had RA. The odds ratios (OR) of CVD comorbidities were increased in RA patients; ischemic heart disease (IHD: OR 1.75; 95% CI 1.73, 1.77), cerebral infarction (CERI: OR 1.28; 95% CI 1.26, 1.30), hypertension (HTN: OR 1.44; 95% CI 1.43, 1.45), diabetes mellitus (DM: OR 2.04; 95% CI 2.03, 2.06), and dyslipidemia (DL: OR 3.49; 95% CI 3.47, 3.51). The ORs of IHD, CERI, HTN, and DM in the traditional DMARD and biologic treatment groups were decreased, compared with those in the non-pharmacotherapy group. Conclusions: Thus, CVD risk was higher in RA patients, considering age, sex, and socioeconomic status. Appropriate pharmacotherapy could decrease the risk of CVD comorbidities in RA patients.
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참고문헌 (33)
참고문헌 신청
Scott DL / 2010 / Rheumatoid arthritis / Lancet 376:1094~1108
Silman AJ / 2002 / Epidemiology and genetics of rheumatoid arthritis / Arthritis Res 4(suppl):S265~S272
Hunter TM / 2017 / Prevalence of rheumatoid arthritis in the United States adult population in healthcare claims databases, 2004-2014 / Rheumatol Int 37(9):1551~1557
Minichiello E / 2016 / Time trends in the incidence, prevalence, and severity of rheumatoid arthritis: A systematic literature review / Joint Bone Spine 83(6):625~630
Naqvi AA / 2019 / Epidemiology of rheumatoid arthritis, clinical aspects and socio-economic determinants in Pakistani patients: A systematic review and meta-analysis / J Pak Med Assoc 69:389~398
Silman AJ / 2002 / Epidemiology and genetics of rheumatoid arthritis / Arthritis Res 4(suppl):S265~S272
Hunter TM / 2017 / Prevalence of rheumatoid arthritis in the United States adult population in healthcare claims databases, 2004-2014 / Rheumatol Int 37(9):1551~1557
Minichiello E / 2016 / Time trends in the incidence, prevalence, and severity of rheumatoid arthritis: A systematic literature review / Joint Bone Spine 83(6):625~630
Naqvi AA / 2019 / Epidemiology of rheumatoid arthritis, clinical aspects and socio-economic determinants in Pakistani patients: A systematic review and meta-analysis / J Pak Med Assoc 69:389~398
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