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Objective: To investigate the effect of Alpiniae oxyphyllae fructus (AOF) on the alleviation of musculoskeletal disorders caused by aging, we conducted experiments on osteoporosis and muscle atrophy. Methods: The experimental group was classified into a control group, aging-elicited (AE) group and AOF group. The control group comprised 8-week-old Institute of Cancer Research (ICR) mice. The AE and AOF groups were ICR mice at 50 weeks of age. For the AE group, 10 mL of distilled water was administered once a day for 180 days without any treatment. An AOF extract (0.54 g/kg) was dissolved in distilled water and administered to the mice in the AOF group once a day for 180 days. Results: In the experiment on the alleviation of osteoporosis, the distribution of glucosaminoglycan in the bone matrix of the femoral bone was increased in the AOF group; moreover, the osteocalcin (OCN) positive reaction was increased and 8-OHdG positivity was decreased. In addition, AOF positively decreased RANKL, positively increased OPG, and positively decreased MMP-3. Muscle fiber loss in the endomysium following muscle degeneration of the quadriceps was reduced more in the AOF group compared with the AE group, and caspase-3 positive responses were also decreased. In addition, the 8-OHdG and p-lkB positivity in the AOF group decreased compared with the AE group, and the Myo-D positivity increased. Conclusion: We found that increasing bone formation alleviates osteoporosis, and that reducing bone loss alleviates muscle atrophy by reducing muscle loss and increasing muscle development
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참고문헌 (40)
참고문헌 신청
Sherwood L / 2016 / Human Physiology / Life science :732
Translated by professors from national medical university / 2002 / Review of medical physiology / Hanwoori :67~70
Nader GA / 2005 / Molecular determinants of skeletal muscle mass:getting the “AKT” together / Int J Biochem Cell Biol 37(10):1985~1996
Ehrenborg E / 2009 / Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta / Pharmacol Rev 61(3):373~393
Frontera WR / 2015 / Skeletal muscle:a brief review of structure and function / Calcif Tissue Int 96(3):183~195
Translated by professors from national medical university / 2002 / Review of medical physiology / Hanwoori :67~70
Nader GA / 2005 / Molecular determinants of skeletal muscle mass:getting the “AKT” together / Int J Biochem Cell Biol 37(10):1985~1996
Ehrenborg E / 2009 / Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta / Pharmacol Rev 61(3):373~393
Frontera WR / 2015 / Skeletal muscle:a brief review of structure and function / Calcif Tissue Int 96(3):183~195
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