Effect of alendronate on muscle mass: Investigation in patients with osteoporosis

Atsushi Harada; Sadayuki Ito; Yasumoto Matsui; Yoshihito Sakai; Marie Takemura; Haruhiko Tokuda; Tetsuro Hida; Hiroshi Shimokata

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자료유형: 학술저널

저자정보: Atsushi Harada (Department of Orthopedic Surgery National Center) Sadayuki Ito (Department of Orthopedic Surgery National Center) Yasumoto Matsui (Department of Orthopedic Surgery National Center) Yoshihito Sakai (Department of Orthopedic Surgery National Center) Marie Takemura (Department of Orthopedic Surgery National Center) Haruhiko Tokuda (Department of Clinical Laboratory National Center) Tetsuro Hida (Department of Orthopedic Surgery Nagoya Universit) Hiroshi Shimokata (Graduate School of Nutritional Sciences Nagoya Un)

저널정보: 대한골다공증학회 Osteoporosis and Sarcopenia Osteoporosis and Sarcopenia Vol.1 No.1

발행연도: 2015.1

수록면: 53 - 58 (6page)

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Objectives: Many osteoporosis drugs reliably increase bone mass in the elderly; if these drugs also had a positive effect on muscle, their benefit would be even greater. We examined the effect of alendronate monotherapy on muscle mass in patients with osteoporosis. Methods: In this retrospective cohort, case-control study, patients from an osteoporosis database were divided into 2 groups: alendronate-treated patients (group A; n ¼ 199) and a control group receiving no drug treatment (group C; n ¼ 233). Appendicular skeletal muscle mass (ASM) and skeletal muscle mass index (SMI) measured by dual-energy X-ray absorptiometry were assessed at approximately 1 year. The change in muscle mass was compared between the groups. Results: At baseline, group A included more women and had lower height, weight, bone mineral content, and muscle mass than group C. A comparison of changes after 1 yeardadjusted for age, sex, observation period, body mass index and initial valuesdrevealed that the muscle mass in group A showed increases by 0.137 kg/m2 in SMI, 514 g in ASM, and 319 g in lower limb muscle mass (LLM). Group C showed no changes in muscle mass. A significant difference in the amount of change in ASM and LLM was found between the groups after adjustment: 2.5 times and 4.4 times higher, respectively, in groups A and C. However, the difference in SMI disappeared after adjustment. Conclusions: This is the first study to show that alendronate may have a positive effect not only on bone, but on muscle as well.

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참고문헌 신청

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