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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 56 - 60 (5page)
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초록· 키워드
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Ginsenosides are active constituents of ginseng (Panax ginseng) that have possible anti-aging, physiological and pharmacological activities, such as anti-cancer and anti-inflammatory effects. Although the ginseng root is generally used more often than the aerial parts for medicinal purposes, the flowers also contain numerous ginsenosides, including Rb2, Rc, Rd, Re and Rg1. Therefore, an extract from the flowers of the P. ginseng could have the pharmacological efficacy of bioactive compounds including ginsenosides. The high hydrostatic pressure extraction (HHPE) is a method that is used for the efficient extraction of bioactive compounds from plant materials. In this study, we compared the yield of ginsenosides from ginseng flowers under different conditions of extraction pressure and time of HHPE. The results indicate that the total yield of the ginsenosides improved as the pressure increased from 0.1 to 80 MPa and treatment duration increased to 24 hours. In addition, the ginsenoside extracts from HHPE at 80 MPa, which possessed a higher total ginsenoside concentration, decreased the viability of the primary human epidermal keratinocytes (HEKs) significantly than the ginsenoside extracts from HHPE at 0.1 MPa. Collectively, we found that the method of HHPE that was performed for 24 hours at 80 MPa showed the highest yield of ginsenosides from the flowers of P. ginseng. In addition, our study provides a foundation for the efficient extraction of ginsenosides, which had a potent bioactivity, from flowers of P. ginseng through HHPE.
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참고문헌 (18)
참고문헌 신청
Ali MB / 2006 / Phenolics metabolism and lignin synthesis in root suspension cultures of Panax ginseng in response to copper stress / Plant Sci 171:147~154
Chen R / 2009 / Effects of ultrahigh pressure extraction conditions on yields and antioxidant activity of ginsenoside from ginseng / Sep Purif Technol 66:340~346
Chen Y / 2016 / 20(S)-ginsenoside Rh2 inhibits the proliferation and induces the apoptosis of KG-1a cells through the Wnt/β-catenin signaling pathway / Oncol Rep 36:137~146
Jia L / 2009 / Current evaluation of the millennium phytomedicine-ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine / Curr Med Chem 16:2924~2942
Kazuhiro H / 1991 / Polyacetylenes from the roots of Panax ginseng / Phytochemistry 30:3327~3333
Chen R / 2009 / Effects of ultrahigh pressure extraction conditions on yields and antioxidant activity of ginsenoside from ginseng / Sep Purif Technol 66:340~346
Chen Y / 2016 / 20(S)-ginsenoside Rh2 inhibits the proliferation and induces the apoptosis of KG-1a cells through the Wnt/β-catenin signaling pathway / Oncol Rep 36:137~146
Jia L / 2009 / Current evaluation of the millennium phytomedicine-ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine / Curr Med Chem 16:2924~2942
Kazuhiro H / 1991 / Polyacetylenes from the roots of Panax ginseng / Phytochemistry 30:3327~3333
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