지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 4 - 15 (12page)
이용수
초록· 키워드
오류제보하기
havioral, psychophysiological, neurobiological, and genetic data. Molecular genetic research on PD is specifically focused on neurotransmitters, including serotonin, neuropeptides, glucocorticoids, and neurotrophins. Although pharmacological interventions for PD are currently available, the need for more effective, faster-acting, and more tolerable pharmacological interventions is unmet. Thus, glutamatergic receptor modulators, orexin receptor antagonists, corticotrophin-releasing factor 1 receptor antagonists, and other novel mechanism-based anti-panic therapeutics have been proposed. Research on the neural correlates of PD is focused on the dysfunctional “cross-talk” between emotional drive (limbic structure) and cognitive inhibition (prefrontal cortex) and the fear circuit, which includes the amygdala-hippocampus-prefrontal axis. The neural perspective regarding PD supports the idea that cognitive-behavioral therapy normalizes alterations in top-down cognitive processing, including increased threat expectancy and attention to threat. Consistent with the concept of “personalized medicine,” it is speculated that Research Domain Criteria can enlighten further treatments targeting dysfunctions underlying PD more precisely and provide us with better definitions of moderators used to identify subgroups according to different responses to treatment. Structuring of the “negative valence systems” domain, which includes fear/anxiety, is required to define PD. Therefore, targeting glutamate- and orexin-related molecular mechanisms associated with the fear circuit, which includes the amygdala- hippocampus-prefrontal cortex axis, is required to define a novel bio-psychosocial-behavioral treatment model of PD.
목차
등록된 정보가 없습니다.
참고문헌 (125)
참고문헌 신청
de Jonge P / 2016 / Cross-national epidemiology of panic disorder and panic attacks in the World Mental Health Surveys / Depress Anxiety 33:1155~1177
Roy-Byrne PP / 2000 / Lifetime panic-depression comorbidity in the National Comorbidity Survey. Association with symptoms, impairments, course and help-seeking / Br J Psychiatry 176:229~235
Lepine JP / 2001 / Epidemiology, burden, and disability in depression and anxiety / J Clin Psychiatry 62(Suppl 13):4~10
Lepine JP / 2002 / The epidemiology of anxiety disorders: prevalence and societal costs / J Clin Psychiatry 63(Suppl 14):4~8
Collins PY / 2011 / Scientific Advisory Board and the Executive Committee of the Grand Challenges on Global Mental Health. Grand challenges in global mental health / Nature 475:27~30
Roy-Byrne PP / 2000 / Lifetime panic-depression comorbidity in the National Comorbidity Survey. Association with symptoms, impairments, course and help-seeking / Br J Psychiatry 176:229~235
Lepine JP / 2001 / Epidemiology, burden, and disability in depression and anxiety / J Clin Psychiatry 62(Suppl 13):4~10
Lepine JP / 2002 / The epidemiology of anxiety disorders: prevalence and societal costs / J Clin Psychiatry 63(Suppl 14):4~8
Collins PY / 2011 / Scientific Advisory Board and the Executive Committee of the Grand Challenges on Global Mental Health. Grand challenges in global mental health / Nature 475:27~30
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