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자료유형
학술저널
저자정보
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제51권 제1호
발행연도
2019.1
수록면
357 - 367 (11page)

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Purpose Dexrazoxane has been used as an effective cardioprotector against anthracycline cardiotoxicity. This study intended to analyze cardioprotective efficacy and secondary malignancy development, and elucidate risk factors for secondary malignancies in dexrazoxane-treated pediatric patients. Materials and Methods Data was collected from 15 hospitals in Korea. Patients who received any anthracyclines, and completed treatment without stem cell transplantation were included. For efficacy evaluation, the incidence of cardiac events and cardiac event-free survival rates were compared. Data about risk factors of secondary malignancies were collected. Results Data of total 1,453 cases were analyzed; dexrazoxane with every anthracyclines group (D group, 1,035 patients) and no dexrazoxane group (non-D group, 418 patients). Incidence of the reported cardiac events was not statistically different between two groups; however, the cardiac event-free survival rate of patients with more than 400 mg/m2 of anthracyclines was significantly higher in D group (91.2% vs. 80.1%, p=0.04). The 6-year cumulative incidence of secondary malignancy was not different between both groups after considering follow-up duration difference (non-D, 0.52%±0.37%; D, 0.60%±0.28%; p=0.55). The most influential risk factor for secondary malignancy was the duration of anthracycline administration according to multivariate analysis. Conclusion Dexrazoxane had an efficacy in lowering cardiac event-free survival rates in patients with higher cumulative anthracyclines. As a result of multivariate analysis for assessing risk factors of secondary malignancy, the occurrence of secondary malignancy was not related to dexrazoxane administration.

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참고문헌 (21)

참고문헌 신청
Harake D / 2012 / Cardiotoxicity in childhood cancer survivors : strategies for prevention and management / Future Cardiol 8:647~670 google schola Brewster DH / 2014 / Subsequent hospitalisation experience of 5-year survivors of childhood, adolescent, and young adult cancer in Scotland : a population based, retrospective cohort study / Br J Cancer 110:1342~1350 google schola 최형수 / 2010 / Dexrazoxane for Preventing Anthracycline Cardiotoxicity in Children with Solid Tumors / Journal of Korean Medical Science 25(9):1336~1342 dbpia Barry EV / 2008 / Absence of secondary malignant neoplasms in children with high-risk acute lymphoblastic leukemia treated with dexrazoxane / J Clin Oncol 26:1106~1111 google schola Tebbi CK / 2007 / Dexrazoxane-associated risk for acute myeloid leukemia/myelodysplastic syndrome and other secondary malignancies in pediatric Hodgkin's disease / J Clin Oncol 25:493~500 google schola

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