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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 434 - 437 (4page)
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초록· 키워드
오류제보하기
Ingenol mebutate (IM) is approved for the treatment of actinic keratosis and induces cell death in precancerous lesions. The efficacy of IM in the treatment of genital warts was investigated in a therapy-refractory patient. The 74-year-old male was treated with IM gel for three consecutive days. Treatment course and efficacy were evaluated by clinical inspection and non-invasive diagnostics namely optical coherence tomography (OCT) and reflectance confocal microscopy (RCM). Within 24 to 48 hours IM induced a strong local inflammatory reaction. One week later a complete response was observed. OCT and RCM showed a strong reaction after treatment with erosions, swelling of cells, and a subepidermal dark band in representative lesions. IM has the advantage of a short treatment period in contrast to other topical treatments and shows a promising clinical outcome. Larger studies are needed to validate the data.
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등록된 정보가 없습니다.
참고문헌 (4)
참고문헌 신청
Khawaja HT / 1989 / Podophyllin versus scissor excision in the treatment of perianal condylomata acuminata : a prospective study / Br J Surg 76:1067~1068
Braun SA / 2015 / Successful therapy of condylomata acuminata with ingenol mebutate / Hautarzt 66:223~225
Rosen RH / 2012 / Dual mechanism of action of ingenol mebutate gel for topical treatment of actinic keratoses : rapid lesion necrosis followed by lesion-specific immune response / J Am Acad Dermatol 66:486~493
Ogbourne SM / 2004 / Antitumor activity of 3-ingenyl angelate : plasma membrane and mitochondrial disruption and necrotic cell death / Cancer Res 64:2833~2839
Braun SA / 2015 / Successful therapy of condylomata acuminata with ingenol mebutate / Hautarzt 66:223~225
Rosen RH / 2012 / Dual mechanism of action of ingenol mebutate gel for topical treatment of actinic keratoses : rapid lesion necrosis followed by lesion-specific immune response / J Am Acad Dermatol 66:486~493
Ogbourne SM / 2004 / Antitumor activity of 3-ingenyl angelate : plasma membrane and mitochondrial disruption and necrotic cell death / Cancer Res 64:2833~2839
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