지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 21 - 27 (7page)
이용수
초록· 키워드
오류제보하기
Objectives: The present study was undertaken to evaluate the immunomodulatory (IM) activity of IM-133N, a herbal combination in various immunotherapeutic experimental models.
Methods: The IM activity of IM-133N was evaluated against three experimental models namely, effect of IM- 133N against Escherichia coli (E. coli)-induced abdominal sepsis in mice, and carbon clearance test was performed in Wistar albino rats to evaluated the phagocytic potential of IM-133N, in addition IM-133N was evaluated for its immunoglobulin enhancing potential in rats, where the immunoglobulin levels were measured by zinc sulphate turbity (ZST) test. Further, IM-133N was subjected for detailed liquid chromatography-mass spectrometry (LC-MS)/MS analysis to identify the probable active constituents present in it.
Results: The findings of the present study has demonstrated very promising IM property of IM-133N in all the experimental models. Briefly, pretreatment with IM-133N at 125, 250, 500 and 1,000 mg/kg, p.o. doses had protected the mice against E. coli-induced abdominal sepsis and mortality, further the effect of IM- 133N was found to be significant and dose-dependent.
In support of this, in another study administration of IM-133N showed a significant and dose-dependent increase in serum immunoglobulin levels, estimated by ZST test. In line with the above findings, in the carbon clearance test the low doses (125 and 250 mg/ kg, p.o.) of IM-133N increased the rate of carbon clearance, whereas the higher doses (500 and 1,000 mg/kg, p.o.) did not sustain the response, and saturation effect was considered as one of the possible reason for futility of higher doses for IM-133N. In addition, A detailed LC-MS/MS analysis of IM-133N showed 17 bioactive phytochemical constituents: namely, apigenin, chaulmoogric acid, mesquitol, quercetin, symphoxanthone, salireposide, β-sitosterol, nonaeicosanol, β-amyrin, betulic acid, oleanolic acid, symplososide, symponoside, symploveroside, symplocomoside, symconoside A and locoracemoside B.
Conclusion: These findings suggest that IM-133N possesses significant IM activity and, hence, could be useful for eradicating opportunistic disease-triggering pathogens via immunotherapeutic mechanisms. The findings also suggest IM-133N may also useful in other immunity disorders.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Chahar MK / 2012 / In-vivo antioxidant and immunomodulatory activity of mesuol isolated from Mesua ferrea L. seed oil / Int Immunopharmacol 3(4):386~391
Kumar D / 2012 / A review of immunomodulators in the Indian traditional health care system / J Microbiol Immunol Infect 45(3):165~184
Sagrawat H / 2007 / Immunomodulatory plants: a phytopharmacological review / Pharmacog Rev 1:248~260
Wichers H / 2009 / Immunomodulation by food : promising concept for mitigating allergic disease? / Anal Bioanal Chem 395(1):37~45
Aranha I / 2012 / Immunostimulatory properties of the major protein from the stem of the Ayurvedic medicinal herb, guduchi(Tinospora cordifolia) / J Ethnopharmacol 139(2):366~372
Kumar D / 2012 / A review of immunomodulators in the Indian traditional health care system / J Microbiol Immunol Infect 45(3):165~184
Sagrawat H / 2007 / Immunomodulatory plants: a phytopharmacological review / Pharmacog Rev 1:248~260
Wichers H / 2009 / Immunomodulation by food : promising concept for mitigating allergic disease? / Anal Bioanal Chem 395(1):37~45
Aranha I / 2012 / Immunostimulatory properties of the major protein from the stem of the Ayurvedic medicinal herb, guduchi(Tinospora cordifolia) / J Ethnopharmacol 139(2):366~372
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