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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 617 - 627 (11page)
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초록· 키워드
오류제보하기
Brain organoids are an exciting new technology with the potential to significantly change our understanding of the development and disorders of the human brain. With step-by-step differentiation protocols, three-dimensional neural tissues are self-organized from pluripotent stem cells, and recapitulate the major millstones of human brain development in vitro. Recent studies have shown that brain organoids can mimic the spatiotemporal dynamicity of neurogenesis, the formation of regional neural circuitry, and the integration of glial cells into a neural network. This suggests that brain organoids could serve as a representative model system to study the human brain. In this review, we will overview the development of brain organoid technology, its current progress and applications, and future prospects of this technology.
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참고문헌 (94)
참고문헌 신청
Bian, S. / 2018 / Genetically engineered cerebral organoids model brain tumor formation / Nat. Methods 15:631~639
Birey, F. / 2017 / Assembly of functionally integrated human forebrain spheroids / Nature 545:54~59
Buchanan, M. / 2018 / Organoids of intelligence / Nat. Phys 14:634
Calvet, G. / 2016 / Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil : a case study / Lancet Infect. Dis 16:653~660
Camp, J. G. / 2015 / Human cerebral organoids recapitulate gene expression programs of fetal neocortex development / Proc. Natl. Acad. Sci. U. S. A 112:15672~15677
Birey, F. / 2017 / Assembly of functionally integrated human forebrain spheroids / Nature 545:54~59
Buchanan, M. / 2018 / Organoids of intelligence / Nat. Phys 14:634
Calvet, G. / 2016 / Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil : a case study / Lancet Infect. Dis 16:653~660
Camp, J. G. / 2015 / Human cerebral organoids recapitulate gene expression programs of fetal neocortex development / Proc. Natl. Acad. Sci. U. S. A 112:15672~15677
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