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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 122 - 130 (9page)
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초록· 키워드
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Objectives: The medicinal plants are believed to enhance the natural resistance of the body to infections. Some of the main constituents of the plant and derived materials such as, proteins, lectins and polysaccharides have anti-inflammatory effects. Portulaca oleracea (P. oleracea) were used traditionally for dietary, food additive, spice and various medicinal purposes. This review article is focus on the anti-asthmatic effects of P. oleracea and its constituents. Methods: Various databases, such as the PubMed, Scopus, and Google Scholar, were searched the keywords including "Portulaca oleracea", "Quercetin", "Anti-inflammatory", "Antioxidant", "Cytokines", "Smooth muscle ", and " Relaxant effects " until the end of Jul 2018. Results: P. oleracea extracts and its constituents increased IFN-γ, IL-2, IFNγ/IL-4 and IL- 10/IL-4 ratio, but decreased secretion of TNF-α, IL-4 and chemokines in both in vitro and in vivo studies. P. oleracea extracts and quercetin also significantly decreased production of NO,stimulated β-adrenoceptor and/or blocking muscarinic receptors in tracheal smooth muscles. Conclusion: P. oleracea extracts and quercetin showed relatively potent anti-asthmatic effects due to decreased production of NO, inflammatory cytokines and chemokines, reduced oxidant while enhanced antioxidant markers, and also showed potent relaxant effects on tracheal smooth muscles via stimulatory on β-adrenoceptor or/and blocking muscarinic receptors.
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등록된 정보가 없습니다.
참고문헌 (68)
참고문헌 신청
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Anderson GP / 1994 / TH2 and ‘TH2-like’cells in allergy and asthma : pharmacological perspectives / Trends pharm sci 15(9):324~332
Hoogsteden H / 1999 / Airway inflammation in asthma and chronic obstructive pulmonary disease with special emphasis on the antigen presenting dendritic cell : influence of treatment with fluticasone propionate / Clin Exp All 29:116~124
Janssen LJ / 2006 / Airway smooth muscle as a target of asthma therapy : history and new directions / Resp res 7(1):123
Barnes PJ. / 2006 / Corticosteroids: the drugs to beat / Eur j pharmacol 533(1-3):2~14
Anderson GP / 1994 / TH2 and ‘TH2-like’cells in allergy and asthma : pharmacological perspectives / Trends pharm sci 15(9):324~332
Hoogsteden H / 1999 / Airway inflammation in asthma and chronic obstructive pulmonary disease with special emphasis on the antigen presenting dendritic cell : influence of treatment with fluticasone propionate / Clin Exp All 29:116~124
Janssen LJ / 2006 / Airway smooth muscle as a target of asthma therapy : history and new directions / Resp res 7(1):123
Barnes PJ. / 2006 / Corticosteroids: the drugs to beat / Eur j pharmacol 533(1-3):2~14
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