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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 628 - 636 (9page)
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Altered genetic features in cancer cells lead to a high rate of aerobic glycolysis and metabolic reprogramming that is essential for increased cancer cell viability and rapid proliferation. Pyruvate kinase muscle (PKM) is a rate-limiting enzyme in the final step of glycolysis. Herein, we report that PKM is a potential therapeutic target in triple-negative breast cancer (TNBC) cells. We found that PKM1 or PKM2 is highly expressed in TNBC tissues or cells. Knockdown of PKM significantly suppressed cell proliferation and migration, and strongly reduced S phase and induced G2 phase cell cycle arrest by reducing phosphorylation of the CDC2 protein in TNBC cells. Additionally, knockdown of PKM significantly suppressed NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity by reducing the phosphorylation of p65 at serine 536, and also decreased the expression of NF-kB target genes. Taken together, PKM is a potential target that may have therapeutic implications for TNBC cells.
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참고문헌 (43)
참고문헌 신청
Anastasiou, D. / 2011 / Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses / Science 334:1278~1283
Azoitei, N. / 2016 / PKM2 promotes tumor angiogenesis by regulating HIF-1alpha through NF-kappaB activation / Mol. Cancer 15:3
Barbie, T. U. / 2014 / Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth / J. Clin. Invest 124:5411~5423
Bianchini, G. / 2016 / Triple-negative breast cancer : challenges and opportunities of a heterogeneous disease / Nat. Rev. Clin. Oncol 13:674~690
Bonotto, M. / 2014 / Measures of outcome in metastatic breast cancer : insights from a real-world scenario / Oncologist 19:608~615
Azoitei, N. / 2016 / PKM2 promotes tumor angiogenesis by regulating HIF-1alpha through NF-kappaB activation / Mol. Cancer 15:3
Barbie, T. U. / 2014 / Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth / J. Clin. Invest 124:5411~5423
Bianchini, G. / 2016 / Triple-negative breast cancer : challenges and opportunities of a heterogeneous disease / Nat. Rev. Clin. Oncol 13:674~690
Bonotto, M. / 2014 / Measures of outcome in metastatic breast cancer : insights from a real-world scenario / Oncologist 19:608~615
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