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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1 - 9 (9page)
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In the present study, the protective effects of Hizikia fusiforme and Chlorella sp. extracts on lead acetate-induced hepatotoxicity were investigated. Hepatic damage was induced in rats by intraperitoneal (i.p.) injection of lead acetate and the protective effects of H. fusiforme (HZK) and Chlorella sp. (CHL) extracts on lead acetate-induced hepatic damage in rat liver were examined. The results revealed significantly increased glutamic oxaloacetate and glutamic pyruvic transaminase levels in the group treated with lead acetate only (Pb group); oral administration of HZK and CHL extracts tended to decrease the enzyme levels similar to those observed in the control group. Regarding antioxidant enzymes, superoxide dismutase activity was increased in the Pb group and decreased in a concentration-dependent manner in the HZK- and CHL-treated groups. Glutathione levels were increased in a concentration-dependent manner in the HZK- and CHL-treated groups. There was no significant difference in catalase activity. Western blot analysis showed inflammation-related protein expression in mitogen-activated protein kinase and Nrf2 pathways was affected in the HZK- and CHL-treated groups. Therefore, HZK and CHL extracts exerted antioxidant and anti-inflammatory effects against lead acetate-induced hepatotoxicity. Development of functional health foods containing HZK and CHL extracts, which have hepatoprotective effects against inhaled lead acetate, should be considered.
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참고문헌 (34)
참고문헌 신청
Aktan F / 2004 / iNOS-mediated nitric oxide production and its regulation / Life Sci 75:639~653
Aránzazu Bocanegra / 2009 / Characteristics and Nutritional and Cardiovascular-Health Properties of Seaweeds / Journal of Medicinal Food 12(2):236~258
Bozena K / 2005 / MAPK signalling pathways as molecular targets for anti-inflammatory therapy from molecular mechanisms to therapeutic benefits / Biochim Biophys Acta 1754:253~262
Cargnello M / 2011 / Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases / Microbiol Mol Biol Rev 75:50~83
Carla SC / 2017 / Data on the effects of losartan on protein expression vascular reactivity and antioxidant capacity in the aorta of ethanol-treated rats / Data Brief 11:111~116
Aránzazu Bocanegra / 2009 / Characteristics and Nutritional and Cardiovascular-Health Properties of Seaweeds / Journal of Medicinal Food 12(2):236~258
Bozena K / 2005 / MAPK signalling pathways as molecular targets for anti-inflammatory therapy from molecular mechanisms to therapeutic benefits / Biochim Biophys Acta 1754:253~262
Cargnello M / 2011 / Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases / Microbiol Mol Biol Rev 75:50~83
Carla SC / 2017 / Data on the effects of losartan on protein expression vascular reactivity and antioxidant capacity in the aorta of ethanol-treated rats / Data Brief 11:111~116
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