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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 102 - 108 (7page)
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Objectives: Esophageal squamous cell carcinoma (ESCC) is considered as a deadly medical condition that affects a growing number of people worldwide. Targeted therapy of ESCC has been suggested recently and required extensive research. With cyclin D1 as a therapeutic target, the present study aimed at evaluating the anticancer effects of doxorubicin (Dox) or Hypericum perforatum L. (HP) extract encapsulated in poly(lactic-co-glycolic acid) (PLGA) nanoparticles on the ESCC cell line KYSE30. Methods: Nanoparticles were prepared using double emulsion method. Cytotoxicity assay was carried out to measure the anti-proliferation activity of Dox-loaded (Dox NPs) and HP-loaded nanoparticles (HP NPs) against both cancer and normal cell lines. The mRNA gene expression of cyclin D1 was evaluated to validate the cytotoxicity studies at molecular level. Results: Free drugs and nanoparticles significantly inhibited KYSE30 cells by 55-73% and slightly affected normal cells up to 29%. The IC50 of Dox NPs and HP NPs was ~ 0.04-0.06 mg/mL and ~ 0.6-0.7 mg/mL, respectively. Significant decrease occurred in cyclin D1 expression by Dox NPs and HP NPs (P < 0.05). Exposure of KYSE-30 cells to combined treatments including both Dox and HP extract significantly increased the level of cyclin D1 expression as compared to those with individual treatments (P < 0.05). Conclusion: Dox NPs and HP NPs can successfully and specifically target ESCC cells through downregulation of cyclin D1. The simultaneous use of Dox and HP extract should be avoided for the treatment of ESCC.
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참고문헌 (48)
참고문헌 신청
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Yadav AK / 2007 / Development and characterization of hyaluronic acid–anchored PLGA nanoparticulate carriers of doxo-rubicin / Nanomedicine : Nanotechnology, Biology and Medicine 3(4):246~257
Abbas G / 2017 / Overview of esophageal cancer / Annals of cardiothoracic surgery 6(2):131~136
Chen Z / 2017 / Incidence and survival differences in esophageal cancer among ethnic groups in the United States / Oncotarget 8(29):47037~47051
Rafiemanesh H / 2016 / The trend in histological changes and the incidence of esophagus cancer in Iran(2003-2008) / Int J Prev Med 7(1):31
Yadav AK / 2007 / Development and characterization of hyaluronic acid–anchored PLGA nanoparticulate carriers of doxo-rubicin / Nanomedicine : Nanotechnology, Biology and Medicine 3(4):246~257
Abbas G / 2017 / Overview of esophageal cancer / Annals of cardiothoracic surgery 6(2):131~136
Chen Z / 2017 / Incidence and survival differences in esophageal cancer among ethnic groups in the United States / Oncotarget 8(29):47037~47051
Rafiemanesh H / 2016 / The trend in histological changes and the incidence of esophagus cancer in Iran(2003-2008) / Int J Prev Med 7(1):31
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