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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제5호
- 발행연도
- 2019.1
- 수록면
- 329 - 334 (6page)
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초록· 키워드
오류제보하기
Diabetes is associated with an increased risk of cardiovascular complications. Dipeptidyl peptidase-4 (DPP-IV) inhibitors are used clinically to reduce high blood glucose levels as an antidiabetic agent. However, the effect of the DPP-IV inhibitor gemigliptin on ischemia/reperfusion (I/R)-induced myocardial injury and hypertension is unknown. In this study, we assessed the effects and mechanisms of gemigliptin in rat models of myocardial I/R injury and spontaneous hypertension. Gemigliptin (20 and 100 mg/kg/d) or vehicle was administered intragastrically to Sprague–Dawley rats for 4 weeks before induction of I/R injury. Gemigliptin exerted a preventive effect on I/R injury by improving hemodynamic function and reducing infarct size compared to the vehicle control group. Moreover, administration of gemigliptin (0.03% and 0.15%) powder in food for 4 weeks reversed hypertrophy and improved diastolic function in spontaneously hypertensive rats. We report here a novel effect of the gemigliptin on I/R injury and hypertension.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Daousi C / 2006 / Prevalence of obesity in type 2 diabetes in secondary care : association with cardiovascular risk factors / Postgrad Med J 82:280~284
Haffner SM / 1998 / Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction / N Engl J Med 339:229~234
Rao Kondapally Seshasai S / 2011 / Diabetes mellitus, fasting glucose, and risk of cause-specific death / N Engl J Med 364:829~841
Martín-Timón I / 2014 / Type 2 diabetes and cardiovascular disease: have all risk factors the same strength? / World J Diabetes 5:444~470
Dardano A / 2014 / Optimal therapy of type 2 diabetes : a controversial challenge / Aging(Albany NY) 6:187~206
Haffner SM / 1998 / Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction / N Engl J Med 339:229~234
Rao Kondapally Seshasai S / 2011 / Diabetes mellitus, fasting glucose, and risk of cause-specific death / N Engl J Med 364:829~841
Martín-Timón I / 2014 / Type 2 diabetes and cardiovascular disease: have all risk factors the same strength? / World J Diabetes 5:444~470
Dardano A / 2014 / Optimal therapy of type 2 diabetes : a controversial challenge / Aging(Albany NY) 6:187~206
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