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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 234 - 243 (10page)
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Objective Working memory impairments serve as prognostic factors for patients with schizophrenia. Working memory deficits are mainly associated with gray matter (GM) thickness and volume. We investigated the association between GM diffusivity and working memory in controls and individuals with schizophrenia. Methods T1 and diffusion tensor images of the brain, working memory task (letter number sequencing) scores, and the demographic data of 90 individuals with schizophrenia and 97 controls were collected from the SchizConnect database. T1 images were parcellated into the 68 GM Regions of Interest (ROI). Axial Diffusivity (AD), Fractional Anisotropy (FA), Radial Diffusivity (RD), and Trace (TR) were calculated for each of the ROIs. Results Compared to the controls, schizophrenia group showed significantly increased AD, RD, and TR in specific regions on the frontal, temporal, and anterior cingulate area. Moreover, working memory was negatively correlated with AD, RD, and TR in the lateral orbitofrontal, superior temporal, inferior temporal, and rostral anterior cingulate area on left hemisphere in the individuals with schizophrenia. Conclusion These results demonstrated GM microstructural abnormalities in the frontal, temporal, and anterior cingulate regions of individuals with schizophrenia. Furthermore, these regional GM microstructural abnormalities suggest a neuropathological basis for the working memory deficits observed clinically in individuals with schizophrenia.
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참고문헌 (77)
참고문헌 신청
Lett TA / 2014 / Treating working memory deficits in schizophrenia : a review of the neurobiology / Biol Psychiatry 75:361~370
Green MF / 1996 / What are the functional consequences of neurocognitive deficits in schizophrenia? / Am J Psychiatry 153:321~330
Dazzan P / 2015 / Magnetic resonance imaging and the prediction of outcome in first-episode schizophrenia : a review of current evidence and directions for future research / Schizophr Bull 41:574~583
Karlsgodt KH / 2009 / White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis / Biol Psychiatry 66:562~569
Karlsgodt KH / 2010 / A multimodal assessment of the genetic control over working memory / J Neurosci 30:8197~8202
Green MF / 1996 / What are the functional consequences of neurocognitive deficits in schizophrenia? / Am J Psychiatry 153:321~330
Dazzan P / 2015 / Magnetic resonance imaging and the prediction of outcome in first-episode schizophrenia : a review of current evidence and directions for future research / Schizophr Bull 41:574~583
Karlsgodt KH / 2009 / White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis / Biol Psychiatry 66:562~569
Karlsgodt KH / 2010 / A multimodal assessment of the genetic control over working memory / J Neurosci 30:8197~8202
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