지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제2호
- 발행연도
- 2019.1
- 수록면
- 151 - 159 (9page)
이용수
초록· 키워드
오류제보하기
Pruritus (itching) is classically defined as an unpleasant cutaneous sensation that leads to scratching behavior. Although the scientific criteria of classification for pruritic diseases are not clear, it can be divided as acute or chronic by duration of symptoms. In this study, we investigated whether skin injury caused by chemical (contact hypersensitivity, CHS) or physical (skin-scratching stimulation, SSS) stimuli causes initial pruritus and analyzed gene expression profiles systemically to determine how changes in skin gene expression in the affected area are related to itching. In both CHS and SSS, we ranked the Gene Ontology Biological Process terms that are generally associated with changes. The factors associated with upregulation were keratinization, inflammatory response and neutrophil chemotaxis. The Kyoto Encyclopedia of Genes and Genomes pathway shows the difference of immune system, cell growth and death, signaling molecules and interactions, and signal transduction pathways. Il1a , Il1b and Il22 were upregulated in the CHS, and Tnf , Tnfrsf1b, Il1b, Il1r1 and Il6 were upregulated in the SSS. Trpc1 channel genes were observed in representative itching-related candidate genes. By comparing and analyzing RNA-sequencing data obtained from the skin tissue of each animal model in these characteristic stages, it is possible to find useful diagnostic markers for the treatment of itching, to diagnose itching causes and to apply customized treatment.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Ständer S / 2007 / Clinical classification of itch : a position paper of the International Forum for the Study of Itch / Acta Derm Venereol 87:291~294
Moore C / 2018 / Regulation of pain and itch by TRP channels / Neurosci Bull 34:120~142
Anderson SE / 2011 / The LLNA : a brief review of recent advances and limitations / J Allergy(Cairo) 2011:424203
Honda T / 2013 / Update of immune events in the murine contact hypersensitivity model : toward the understanding of allergic contact dermatitis / J Invest Dermatol 133:303~315
Yamaoka J / 2007 / A transient unresponsive state of selfscratching behaviour is induced in mice by skin-scratching stimulation / Exp Dermatol 16:737~745
Moore C / 2018 / Regulation of pain and itch by TRP channels / Neurosci Bull 34:120~142
Anderson SE / 2011 / The LLNA : a brief review of recent advances and limitations / J Allergy(Cairo) 2011:424203
Honda T / 2013 / Update of immune events in the murine contact hypersensitivity model : toward the understanding of allergic contact dermatitis / J Invest Dermatol 133:303~315
Yamaoka J / 2007 / A transient unresponsive state of selfscratching behaviour is induced in mice by skin-scratching stimulation / Exp Dermatol 16:737~745
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
만성 가려움의 병태생리와 감별 진단 및 치료
Allergy Asthma & Respiratory Diseases
2021 .10
-
가려움증의 기전에 대한 최신 논의 고찰 - 최근의 연구 동향과 위장관계와의 연관성
한방안이비인후피부과학회지
2021 .08
-
Pathophysiological Role of TLR4 in Chronic Relapsing Itch Induced by Subcutaneous Capsaicin Injection in Neonatal Rats
Immune Network
2022 .04
-
재활단계 화상 환자의 가려움증
근관절건강학회지
2016 .04
-
Atypical presentation of complex regional pain syndrome: neuropathic itching - A case report -
Anesthesia and Pain Medicine
2021 .10
-
Considerable Variability in the Efficacy of 8% Capsaicin Topical Patches in the Treatment of Chronic Pruritus in 3 Patients with Notalgia Paresthetica
Annals of Dermatology
2016 .01
-
IL-1 Receptor Dynamics in Immune Cells: Orchestrating Immune Precision and Balance
Immune Network
2024 .06
-
Anti-inflammatory and anti-itching effects of herbal medicine complex extracts (NI-01)
한국실험동물학회 학술발표대회 논문집
2019 .01
-
I-Kappa-B-Zeta Regulates Interleukin-17A/Tumor Necrosis Factor-Alpha Mediated Synergistic Induction of Interleukin-19 and Interleukin-20 in Humane Keratinocytes
Annals of Dermatology
2021 .01
-
한약복합추출물(NI-01)의 항염증 및 소양감 억제 효과
동의생리병리학회지
2020 .12
-
Association of Genetic Polymorphism of IL-2 Receptor Subunit and Tuberculosis Case
대한의생명과학회지
2018 .06
-
Antipruritic effect of curcumin on histamine-induced itching in mice
The Korean Journal of Physiology & Pharmacology
2018 .09
-
Therapeutic Effects of Korean Red Ginseng Extract in a Murine Model of Atopic Dermatitis: Anti-pruritic and Anti-inflammatory Mechanism
Journal of Korean Medical Science
2017 .01
-
IL-1 Receptor Antagonist Reduced Chemical-Induced Keratinocyte Apoptosis through Antagonism to IL-1α/IL-1β
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Association of Single Nucleotide Polymorphisms in Interleukin-12 Receptor (IL-12Rβ1 and IL-12Rβ2) with Asthma in a Korean Population
대한의생명과학회지
2020 .12
-
Predictors of Sick Sinus Syndrome in Patients after Successful Radiofrequency Catheter Ablation of Atrial Flutter
Yonsei Medical Journal
2015 .01
-
mRNA Expression Level of Interleukin Genes in the Determining Phases of Behçet’s Disease
Annals of Dermatology
2015 .01
-
Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps
Allergy, Asthma & Immunology Research
2020 .01
-
Comparison of cytokine genes related with immune responses in canine macrophages using different culture models after infection with Brucella canis
예방수의학회지
2019 .01
-
Expression of Il4rα and Il13rα1 in Gallbladder Cancer
대한외과학회 학술대회 초록집
2021 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0