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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제4호
- 발행연도
- 2019.1
- 수록면
- 263 - 270 (8page)
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초록· 키워드
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Hydrogen sulfide is well-known to exhibit anti-inflammatory and cytoprotective activities, and also has protective effects in the liver. This study aimed to examine the protective effect of hydrogen sulfide in rats with hepatic encephalopathy, which was induced by mild bile duct ligation. In this rat model, bile ducts were mildly ligated for 26 days. Rats were treated for the final 5 days with sodium hydrosulfide (NaHS). NaHS (25 μmol/kg), 0.5% sodium carboxymethyl cellulose, or silymarin (100 mg/kg) was administered intraperitoneally once per day for 5 consecutive days. Mild bile duct ligation caused hepatotoxicity and inflammation in rats. Intraperitoneal NaHS administration reduced levels of aspartate aminotransferase and alanine aminotransferase, which are indicators of liver disease, compared to levels in the control mild bile duct ligation group. Levels of ammonia, a major causative factor of hepatic encephalopathy, were also significantly decreased. Malondialdehyde, myeloperoxidase, catalase, and tumor necrosis factor-α levels were measured to confirm antioxidative and anti-inflammatory effects. N-Methyl-D-aspartic acid (NMDA) receptors with neurotoxic activity were assessed for subunit NMDA receptor subtype 2B. Based on these data, NaHS is suggested to exhibit hepatoprotective effects and guard against neurotoxicity through antioxidant and anti-inflammatory actions.
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참고문헌 (42)
참고문헌 신청
Gow AG / 2017 / Hepatic encephalopathy / Vet Clin North Am Small Anim Pract 47:585~599
Gerber T / 2000 / Hepatic encephalopathy in liver cirrhosis : pathogenesis, diagnosis and management / Drugs 60:1353~1370
Ong JP / 2001 / Hepatic encephalopathy / Eur J Gastroenterol Hepatol 13:325~334
Mas A / 2006 / Hepatic encephalopathy: from pathophysiology to treatment / Digestion 73(Suppl 1):86~93
Ferenci P / 2002 / Hepatic encephalopathy--definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998 / Hepatology 35:716~721
Gerber T / 2000 / Hepatic encephalopathy in liver cirrhosis : pathogenesis, diagnosis and management / Drugs 60:1353~1370
Ong JP / 2001 / Hepatic encephalopathy / Eur J Gastroenterol Hepatol 13:325~334
Mas A / 2006 / Hepatic encephalopathy: from pathophysiology to treatment / Digestion 73(Suppl 1):86~93
Ferenci P / 2002 / Hepatic encephalopathy--definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998 / Hepatology 35:716~721
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