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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제8호
- 발행연도
- 2019.1
- 수록면
- 1,204 - 1,211 (8page)
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초록· 키워드
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Fungal exopolysaccharides are important natural products having diverse biological functions. In this study, exopolysaccharides from Fomitopsis castanea mycelia (FEPS) were prepared, and the highest mushroom tyrosinase inhibitory activity was found. FEPS were prepared from cultivation broth by ethanol precipitation method. The extraction yield and protein concentration of FEPS were 213.1 mg/l and 0.03%, respectively. FEPS inhibited mushroom tyrosinase with the half maximal inhibitory concentration (IC50) of 16.5 mg/ml and dose-dependently inhibited cellular tyrosinase activity (63.9% at 50 μg/ml, and 83.3% at 100 μg/ml) in the cell-free extract of SK-MEL-5 human melanoma cell and α-melanocytestimulating hormone (α-MSH)-stimulated melanin formation in intact SK-MEL-5 human melanoma cell. The IC50 of FEPS against NO production from RAW264.7 macrophage cells was 42.8 ± 0.64 μg/ml. By in vivo study using a zebrafish model, exposure of FEPS at 400 μg/ml to dechorionated zebrafish embryos for 18 h decreased the pigment density, compared to that without FEPS-treated control.
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참고문헌 (44)
참고문헌 신청
Wasser SP / 2011 / Current findings, future trends, and unsolved problems in studies of medicinal mushrooms / Appl. Microbiol. Biotechnol 89:1323~1332
Bajpai VK / 2016 / Partially purified exopolysaccharide from Lactobacillus Sakei Probio 65 with antioxidant, α-glucosidase and tyrosinase inhibitory potential / J. Food Biochem 40:264~274
Wang HX / 1996 / Polysaccharide-peptide complexes from the cultured mycelia of the mushroom Coriolus versicolor and their culture medium activate mouse lymphocytes and macrophages / Int. J. Biochem. Cell B 28:601~607
Lee JS / 2009 / Study on macrophage activation and structural characteristics of purified polysaccharides from the liquid culture broth of Hericium erinaceus / Carbohydr. Polym 78:162~168
Cheng JJ / 2008 / Properties and biological functions of polysaccharides and ethanolic extracts isolated from medicinal fungus, Fomitopsis pinicola / Process Biochem 43:829~834
Bajpai VK / 2016 / Partially purified exopolysaccharide from Lactobacillus Sakei Probio 65 with antioxidant, α-glucosidase and tyrosinase inhibitory potential / J. Food Biochem 40:264~274
Wang HX / 1996 / Polysaccharide-peptide complexes from the cultured mycelia of the mushroom Coriolus versicolor and their culture medium activate mouse lymphocytes and macrophages / Int. J. Biochem. Cell B 28:601~607
Lee JS / 2009 / Study on macrophage activation and structural characteristics of purified polysaccharides from the liquid culture broth of Hericium erinaceus / Carbohydr. Polym 78:162~168
Cheng JJ / 2008 / Properties and biological functions of polysaccharides and ethanolic extracts isolated from medicinal fungus, Fomitopsis pinicola / Process Biochem 43:829~834
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