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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 166 - 174 (9page)
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초록· 키워드
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Bacterial species in the genus Xanthomonas infect virtually all crop plants. Although many genes involved in Xanthomonas virulence have been identified through molecular and cellular studies, the elucidation of virulence-associated regulatory circuits is still far from complete. Functional gene networks have proven useful in generating hypotheses for genetic factors of biological processes in various species. Here, we present a genome-scale co-functional network of Xanthomonas oryze pv. oryzae (Xoo) genes, XooNet (www.inetbio.org/xoonet/), constructed by integrating heterogeneous types of genomics data derived from Xoo and other bacterial species. XooNet contains 106,000 functional links, which cover approximately 83% of the coding genome. XooNet is highly predictive for diverse biological processes in Xoo and can accurately reconstruct cellular pathways regulated by two-component signaling transduction systems (TCS). XooNet will be a useful in silico research platform for genetic dissection of virulence pathways in Xoo.
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등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Bae, H.J / 2017 / Inhibition of the DevSR Two-Component System by Overexpression of Mycobacterium tuberculosis PknB in Mycobacterium smegmatis / Molecules and Cells
Barakat, M. / 2009 / P2CS : a two-component system resource for prokaryotic signal transduction research / BMC Genomics 10:315
Barrett, T. / 2013 / NCBI GEO : archive for functional genomics data sets-update / Nucleic Acids Res 41:D991~D995
Boch, J. / 2010 / Xanthomonas AvrBs3 family-type III effectors : discovery and function / Annu. Rev. Phytopathol 48:419~436
Caspi, R. / 2016 / The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases / Nucleic Acids Res 44:D471~D480
Barakat, M. / 2009 / P2CS : a two-component system resource for prokaryotic signal transduction research / BMC Genomics 10:315
Barrett, T. / 2013 / NCBI GEO : archive for functional genomics data sets-update / Nucleic Acids Res 41:D991~D995
Boch, J. / 2010 / Xanthomonas AvrBs3 family-type III effectors : discovery and function / Annu. Rev. Phytopathol 48:419~436
Caspi, R. / 2016 / The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases / Nucleic Acids Res 44:D471~D480
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