지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 545 - 554 (10page)
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초록· 키워드
오류제보하기
Background: Severe cutaneous adverse reactions (SCAR) to drugs are a crucial public health issue and the use of systemic corticosteroids in SCAR has been controversial. Objective: To analyze clinical features, causative drugs, treatment, outcomes, and prognostic factors of SCAR in the case-series of 173 patients, and add more information to the debate of using systemic corticosteroids in SCAR management. Methods: A retrospective study of 173 SCAR patients diagnosed with drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) or acute generalized exanthematous pustulosis (AGEP) at a tertiary care institution in China between January 2014 and December 2017 was conducted. Results: Of 173 patients, allopurinol, carbamazepine, and antibiotics are the most frequently implicated drugs for DRESS (40.4%), SJS/TEN (26.0%), and AGEP (40.0%) respectively. Moreover, there is a strongly negative correlation between early corticosteroids use and the progression (p=0.000) and severity (p=0.01) of skin lesions. However, there is no association between early corticosteroids use and the mortality of SCAR (odds ratio: 1.01, 95% confidence interval: 0.95∼1.08). In addition, lymphadenopathy, eosinophilia, and interval from onset to corticosteroids treatment were correlated with SCAR prognosis. Conclusion: Prompt short-course systemic corticosteroids use is associated with early-stage skin lesions remission without influencing the disease mortality. Lymphadenopathy and eosinophilia were the independent poor prognostic factors of SCAR.
목차
등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Roujeau JC / 1994 / Severe adverse cutaneous reactions to drugs / N Engl J Med 331:1272~1285
Bocquet H / 1996 / Drug-induced pseudolymphoma and drug hypersensitivity syndrome(Drug Rash with Eosinophilia and Systemic Symptoms : DRESS) / Semin Cutan Med Surg 15:250~257
Kardaun SH / 2007 / Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms : does a DRESS syndrome really exist / Br J Dermatol 156:609~611
Auquier-Dunant A / 2002 / Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis : results of an international prospective study / Arch Dermatol 138:1019~1024
Szatkowski J / 2015 / Acute generalized exanthematous pustulosis(AGEP) : a review and update / J Am Acad Dermatol 73:843~848
Bocquet H / 1996 / Drug-induced pseudolymphoma and drug hypersensitivity syndrome(Drug Rash with Eosinophilia and Systemic Symptoms : DRESS) / Semin Cutan Med Surg 15:250~257
Kardaun SH / 2007 / Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms : does a DRESS syndrome really exist / Br J Dermatol 156:609~611
Auquier-Dunant A / 2002 / Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis : results of an international prospective study / Arch Dermatol 138:1019~1024
Szatkowski J / 2015 / Acute generalized exanthematous pustulosis(AGEP) : a review and update / J Am Acad Dermatol 73:843~848
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