Effects of collimator on imaging performance of Yttrium-90 Bremsstrahlung photons: Monte Carlo simulation

김민호; 배재건; 홍봉환; 김경민; 이원호

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자료유형: 학술저널

저자정보: 김민호 배재건 홍봉환 김경민 이원호

저널정보: 한국원자력학회 Nuclear Engineering and Technology Nuclear Engineering and Technology 제51권 제2호

발행연도: 2019.1

수록면: 539 - 545 (7page)

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연구주제

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연구배경

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연구방법

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연구결과

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Yttrium-90 is a useful therapeutic radioisotope for tumor treatment because of its high-energy-emittingbeta rays. However, it has been difficult to select appropriate collimators and main energy windows forY-90 Bremsstrahlung imaging using gamma cameras because of the broad energy spectra of Y-90. Weused a Monte Carlo simulation to investigate the effects of collimator selection and energy windows onY-90 Bremsstrahlung imaging. We considered both MELP and HE collimators. Various phantoms wereemployed in the simulation to determine the main energy window using primary-to-scatter ratios(PSRs). Imaging performance was evaluated using spatial resolution indices, imaging counts, scatterfractions, and contrast-to-noise ratios. Collimator choice slightly affected energy spectrum shapes andimproved PSRs. The HE collimator performed better than the MELP collimator on all imaging performanceindices (except for imaging count). We observed minor differences in SR and SF values for the HEcollimator among the five simulated energy windows. The combination of an HE collimator andimproved-PSR energy window produced the best CNR value. In conclusion, appropriate collimator selectionis an important component of Bremsstrahlung Y-90 photon imaging and main energy windowdetermination. We found HE collimators to be more appropriate for improving the imaging performanceof Bremsstrahlung Y-90 photons.

참고문헌 (21)

참고문헌 신청

A. Otte / 1999 / Yttrium-90 DOTATOC : first clinical results / Eur. J. Nucl. Med 26:1439~1447

T. E. Witzig / 2002 / Randomized controlled trial of yttrium-90 elabeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-hodgkin’s lymphoma / J. Clin. Oncol 20:2453~2463

F. Morschhauser / 2008 / Phase III trial of consolidation therapy with yttrium-90eibritumomab tiuxetan compared with no additional therapy after first remission in advanced follicular lymphoma / J. Clin. Oncol 26:5156~5164

P. Flamen / 2008 / Multimodality imaging can predict the metabolic response of unresectable colorectal liver metastases to radioembolization therapy with Yttrium-90 labeled resin microspheres / Phys. Med. Biol 53:6591~6603

L. P. Clarke / 1992 / Bremsstrahlung imaging using the gamma camera : factors affecting attenuation / J. Nucl. Med 33:161~166

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