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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 54 - 61 (8page)
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초록· 키워드
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Objective To evaluate the long-term efficacy of mirabegron add-on therapy in patients with spinal cord injury (SCI) based on an urodynamic study. Methods This retrospective study involved a chart audit of individuals with SCI who underwent two consecutive urodynamic studies between April 1, 2015 and April 1, 2018. After adding 50 mg of mirabegron once a day to the pre-existing antimuscarinic therapy for a period of, at least 6 months, the following variables were analyzed: change in cystometric capacity, change in bladder compliance, change in maximal detrusor pressure, change in reflex volume, and presence of significant leakage during filling cystometry. Results A total of 31 participants with a mean age of 41±15 years were included in the analysis. A significant increase in cystometric capacity (mean, 362 to 424 mL; p=0.03), reflex volume (mean, 251 to 329 mL; p=0.02), and bladder compliance (median, 12 to 18 mL/cmH2O; p=0.04) was observed. The presence of leakage during filling cystometry was significantly reduced (29% to 10%; p=0.03). Likewise, a non-significant decrease in the change in maximal detrusor pressure was observed (mean, 31 to 27 cmH2O; p=0.39). Conclusion Adding mirabegron to conventional antimuscarinics further improved urodynamic parameters in patients with chronic SCI, and sustained efficacy was observed in long-term use.
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참고문헌 (30)
참고문헌 신청
Gerridzen RG / 1992 / Risk factors for upper tract deterioration in chronic spinal cord injury patients / J Urol 147:416~418
Goldmark E / 2014 / Neurogenic bladder : from diagnosis to management / Curr Urol Rep 15:448
Abrams P / 2006 / Assessment of treatment outcomes in patients with overactive bladder: importance of objective and subjective measures / Urology 68(2 Suppl):17~28
del Popolo G / 2012 / Controversy over the pharmacological treatments of storage symptoms in spinal cord injury patients : a literature overview / Spinal Cord 50:8~13
Benner JS / 2010 / Patient-reported reasons for discontinuing overactive bladder medication / BJU Int 105:1276~1282
Goldmark E / 2014 / Neurogenic bladder : from diagnosis to management / Curr Urol Rep 15:448
Abrams P / 2006 / Assessment of treatment outcomes in patients with overactive bladder: importance of objective and subjective measures / Urology 68(2 Suppl):17~28
del Popolo G / 2012 / Controversy over the pharmacological treatments of storage symptoms in spinal cord injury patients : a literature overview / Spinal Cord 50:8~13
Benner JS / 2010 / Patient-reported reasons for discontinuing overactive bladder medication / BJU Int 105:1276~1282
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