편백정유의 집먼지 진드기에 의해 활성화된 기관지 상피세포에 미치는 영향

이동원; 강병준; 채미현; 예미경; 신승헌

추천

검색

자료유형: 학술저널

저자정보: 이동원 강병준 채미현 예미경 신승헌

저널정보: 대한이비인후과학회 부산,울산,경남 지부회 임상이비인후과 임상이비인후과 제30권 제1호

발행연도: 2019.1

수록면: 55 - 61 (7page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background and Objectives：The essential oil (EO) from Chamacecyparis obtusa (C. obtusa) has immunological activities with anti-oxidant, anti-inflammatory, and anti-bacterial characteristics. The aim of this study was to investigate the effect of EO from C. obtusa on the house dust mite induced chemical mediator production from bronchial epithelial cells. Materials and Methods：BEAS-2B cells were exposed to Dermatophagoides pteronyssinus (DP) and Dermatophagoides farina (DF) with or without various concentration of EO from C. obtusa. Interleukin-6 (IL-6) and IL-8 were measured to determine the activation of bronchial epithelial cells. Nuclear factor kappa B (NF-κB), activator protein 1 (AP-1), and mitogen-activated protein kinase (MAPK) expression and activity were determined with western blot analysis. Results：DP and DF induced IL-6 and IL-8 production from BEAS-2B cells and these chemical mediator productions were effectively inhibited by 0.02-0.04% of EO. DP and DF enhanced NF-κB and AP-1 transcription factor expression and EO from C. obtusa effectively suppressed the expression and activity of theses transcription factors. Conclusions：EO from C. obtusa suppressed the production of IL-6 and IL-8 with inhibition of the expression and activity of NF-κB and AP-1. EO from C. obtusa is a potential value for the treatment of allergic airway inflammatory diseases

#Essential oilㆍChamacecyparis obtusaㆍHouse dust miteㆍBronchial epithelial cellㆍTranscription factorse.

참고문헌 (21)

참고문헌 신청

Synek M / 1996 / Cellular infiltration of the airways in asthma of varying severity / Am J Respir Crit Care Med 154(1):224~230

Tomee JF / 1998 / Interaction between inhalant extracts and airway epithelial cells: effect on cytokine production and cell detachment / J Allergy Clin Immunol 102(1):78~85

Adam E / 2006 / The house dust mite allergen Der p 1, unlike Der p3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism / J Biol Chem 281(11):6910~6923

Steelant B / 2016 / Impaired barrier function in patients with house dust mite–induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1expression / J Allergy Clin Immunol 137(4):1043~1053

Kato A / 2007 / Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity / Curr Opin Immunol 19(6):711~720

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!