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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The CusBAC heavy metal efflux pump of Escherichia coli consists of three essential components spanning the innermembrane, periplasmic space, and outer membrane. The periplasmic adaptor protein CusB connects the inner membranetransporter CusA to the outer membrane factor CusC. The structural studies revealed that the periplasmic componentCusB has a unique structure in the CusC interaction region. Recent advances in cryo-electron microscopy have revealedthe intermeshing cogwheel interaction between the periplasmic adaptor protein and the outer membrane factor in othertypes of tripartite efflux pumps, such as AcrAB-TolC and MacAB-TolC. In this study, we built a model of the full complexof the CusBAC pump, where the inner α-helices in CusB are twisted inward to make a similar cogwheel structure to thatof AcrA. Binding assay results support the finding that the CusB and CusC binding mode is shared with AcrA and TolC inAcrAB-TolC. Our results give structural insight into a common mechanism for how to seal these proteins to prevent leaks intripartite efflux pumps.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Alav, I. / 2018 / Role of bacterial efflux pumps in biofilm formation / J Antimicrob Chemother 73:2003~2020
Du, D. / 2015 / Assembly and operation of bacterial tripartite multidrug efflux pumps / Trends Microbiol 23:311~319
Du, D. / 2018 / Multidrug efflux pumps : structure, function and regulation / Nat Rev Microbiol 16:523~539
Fitzpatrick, A. W. P. / 2017 / Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump / Nat Microbiol 2:17070
Imperi, F. / 2009 / Molecular basis of pyoverdine siderophore recycling in Pseudomonas aeruginosa / Proc Natl Acad Sci USA 106:20440~20445
Du, D. / 2015 / Assembly and operation of bacterial tripartite multidrug efflux pumps / Trends Microbiol 23:311~319
Du, D. / 2018 / Multidrug efflux pumps : structure, function and regulation / Nat Rev Microbiol 16:523~539
Fitzpatrick, A. W. P. / 2017 / Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump / Nat Microbiol 2:17070
Imperi, F. / 2009 / Molecular basis of pyoverdine siderophore recycling in Pseudomonas aeruginosa / Proc Natl Acad Sci USA 106:20440~20445
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