지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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We reviewed past studies on the identification of familial relationships using 22 short tandem repeat markers. As a result, we can obtain a high discrimination power and a relatively accurate cut-off value in parent-child and full sibling relationships. However, in the case of pairs of uncle-nephew or cousin, we found a limit of low discrimination power of the likelihood ratio (LR) method. Therefore, we compare the LR ranking method and data mining techniques (e.g., logistic regression, linear discriminant analysis, diagonal linear discriminant analysis, diagonal quadratic discriminant analysis, K-nearest neighbor, classification and regression trees, support vector machines, random forest [RF], and penalized multivariate analysis) that can be applied to identify familial relationships, and provide a guideline for choosing the most appropriate model under a given situation. RF, one of the data mining techniques, was found to be more accurate than other methods. The accuracy of RF is 99.99% for parentchild, 99.44% for full siblings, 90.34% for uncle-nephew, and 79.69% for first cousins.
목차
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참고문헌 (22)
참고문헌 신청
Butler JM / 2012 / Biology and genetics of new autosomal STR loci useful for forensic DNA analysis / Forensic Sci Rev 24:15~26
Bieber FR / 2006 / Human genetics : finding criminals through DNA of their relatives / Science 312:1315~1316
Myers SP / 2011 / Searching for first-degree familial relationships in California's offender DNA database : validation of a likelihood ratio-based approach / Forensic Sci Int Genet 5:493~500
Schneider PM / 2007 / Scientific standards for studies in forensic genetics / Forensic Sci Int 165:238~243
이재원 / 2007 / Statistical Evaluation of Sibling Relationship / Communications for Statistical Applications and Methods 14(3):541~549
Bieber FR / 2006 / Human genetics : finding criminals through DNA of their relatives / Science 312:1315~1316
Myers SP / 2011 / Searching for first-degree familial relationships in California's offender DNA database : validation of a likelihood ratio-based approach / Forensic Sci Int Genet 5:493~500
Schneider PM / 2007 / Scientific standards for studies in forensic genetics / Forensic Sci Int 165:238~243
이재원 / 2007 / Statistical Evaluation of Sibling Relationship / Communications for Statistical Applications and Methods 14(3):541~549
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