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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 548 - 553 (6page)
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초록· 키워드
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Ets-1 is a prototype of the ETS protein family. Members of the ETS protein family contain a unique ETS domain. Ets-1 is associated with cancer progression and metastasis in many types of cancer. Many studies have shown a link between elevated expression of Ets-1 in cancer biopsies and poor survival. CCR7 is a chemokine that binds to specific ligand CCL21/CCL19. CCR7 expression is associated with tumor metastasis and infiltration into lymph nodes. The objective of this study was to test whether Ets-1 could regulate CCR7 expression and enhance tumor metastasis. Our data showed that CCR7 expression was downregulated in Ets-1-deficient T cells upon T-cell stimulation. Overexpression of Ets-1 increased CCR7 expression in breast cancer cell lines. In contrast, knockdown of Ets-1 reduced CCR7 expression. Ets-1 could directly bind to CCR7 promoter and mediate CCR7 expression in luciferase reporter assays and chromatin immunoprecipitation assays. Transactivation activity of Ets-1 was independent of the Pointed domain of Ets-1. Ets-1 could also enhance NF-κB and CBP transactivation of CCR7 promoter. Our results also showed that Ets-1 could modulate cancer cell transmigration by altering CCR7 expression in transwell assay and wound healing assay. Taken together, our data suggest that Ets-1 can enhance CCR7 expression and contribute to tumor cell migration.
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참고문헌 (20)
참고문헌 신청
Vela M / 2015 / Chemokine receptor-specific antibodies in cancer immunotherapy : achievements and challenges / Front Immunol 6:12
Zlotnik A / 2004 / Chemokines in neoplastic progression / Semin Cancer Biol 14:181~185
Chen K / 2018 / Chemokines in homeostasis and diseases / Cell Mol Immunol 15:324~334
Al Akoum C / 2015 / NFAT-1, Sp-1, Sp-3, and miR-21 : New regulators of chemokine C receptor 7 expression in mature human dendritic cells / Hum Immunol 76:307~317
Muller A / 2001 / Involvement of chemokine receptors in breast cancer metastasis / Nature 410:50~56
Zlotnik A / 2004 / Chemokines in neoplastic progression / Semin Cancer Biol 14:181~185
Chen K / 2018 / Chemokines in homeostasis and diseases / Cell Mol Immunol 15:324~334
Al Akoum C / 2015 / NFAT-1, Sp-1, Sp-3, and miR-21 : New regulators of chemokine C receptor 7 expression in mature human dendritic cells / Hum Immunol 76:307~317
Muller A / 2001 / Involvement of chemokine receptors in breast cancer metastasis / Nature 410:50~56
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