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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 11 - 15 (5page)
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Previous studies have established a correlation between increasing chronological age and risk of cirrhosis. This pattern raised interest in the role of telomeres and the telomerase complex in the pathogenesis of liver fibrosis and cirrhosis. This review aims to summarize and analyze the current understanding of telomere regulation in hepatocytes and lymphocytes and how this ultimately relates to the development of liver fibrosis. Notably, in chronic viral hepatitis, telomere shortening in hepatocytes and lymphocytes occurs in such a way that may promote further viral replication while also leading to liver damage. However, while telomere shortening occurs in both hepatocytes and lymphocytes and ultimately results in cellular death, the mechanisms of telomere loss appear to be initiated by independent processes. The understanding of telomere maintenance on a hepatic and immune system level in both viral and non-viral etiologies of cirrhosis may open doors to novel therapeutic strategies.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Scaglione S / 2015 / The epidemiology of cirrhosis in the United States : a population-based study / J Clin Gastroenterol 49:690~696
Yim HJ / 2006 / Natural history of chronic hepatitis B virus infection:what we knew in 1981 and what we know in 2005 / Hepatology 43(2 Suppl1):S173~S181
Poynard T / 2001 / Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis C / J Hepatol 34:730~739
Blackburn EH / 2001 / Switching and signaling at the telomere / Cell 106:661~673
Evans SK / 1999 / Telomeres and telomerase : at the end, it all comes together / Trends Cell Biol 9:329~331
Yim HJ / 2006 / Natural history of chronic hepatitis B virus infection:what we knew in 1981 and what we know in 2005 / Hepatology 43(2 Suppl1):S173~S181
Poynard T / 2001 / Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis C / J Hepatol 34:730~739
Blackburn EH / 2001 / Switching and signaling at the telomere / Cell 106:661~673
Evans SK / 1999 / Telomeres and telomerase : at the end, it all comes together / Trends Cell Biol 9:329~331
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