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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 342 - 347 (6page)
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초록· 키워드
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Methylation is a primary epigenetic mechanism regulating gene expression. 5-aza-2’-deoxycytidine is an FDA-approved drug prescribed for treatment of cancer by inhibiting DNA-Methyl-Transferase 1 (DNMT1). Results of this study suggest that prolonged treatment with 5-aza-2’-deoxycytidine could induce centrosome abnormalities in cancer cells and that CEP131, a centrosome protein, is regulated by DNMT1. Interestingly, cancer cell growth was attenuated in vitro and in vivo by inhibiting the expression of Cep131. Finally, Cep131-deficient cells were more sensitive to treatment with DNMT1 inhibitors. These findings suggest that Cep131 is a potential novel anti-cancer target. Agents that can inhibit this protein may be useful alone or in combination with DNMT1 inhibitors to treat cancer.
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참고문헌 (37)
참고문헌 신청
Yen RW / 1992 / Isolation and characterization of the cDNA encoding human DNA methyltransferase / Nucleic Acids Res 20:2287~2291
Guntaka RV / 1987 / Methylation of the enhancer region of avian sarcoma virus long terminal repeat suppresses transcription / FEBS Lett 221:332~336
권유욱 / 2018 / Imprinted gene Zinc finger protein 127 is a novel regulator of master pluripotency transcription factor, Oct4 / BMB Reports 51(5):242~248
Jair KW / 2006 / De novo CpG island methylation in human cancer cells / Cancer Res 66:682~692
Ting AH / 2006 / Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation / Cancer Res 66:729~735
Guntaka RV / 1987 / Methylation of the enhancer region of avian sarcoma virus long terminal repeat suppresses transcription / FEBS Lett 221:332~336
권유욱 / 2018 / Imprinted gene Zinc finger protein 127 is a novel regulator of master pluripotency transcription factor, Oct4 / BMB Reports 51(5):242~248
Jair KW / 2006 / De novo CpG island methylation in human cancer cells / Cancer Res 66:682~692
Ting AH / 2006 / Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation / Cancer Res 66:729~735
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