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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국진공학회(ASCT) Applied Science and Convergence Technology Applied Science and Convergence Technology Vol.24 No.6
- 발행연도
- 2015.11
- 수록면
- 284 - 288 (5page)
이용수
초록· 키워드
오류제보하기
Anionic small molecules are hard to penetrate the cell membranes because of their negative charges. Encapsulation of small molecules into liposome particles can provide target specific delivery of them. In our previous study, siRNA could be efficiently encapsulated into liposome particles using an asymmetric preparation method of liposomes. In this study, the same method was applied for encapsulation of small anionic fluorescent chemicals such as calcein and indocyanine green (ICG). More than 90% fluorescent chemicals were encapsulated in the asymmetric liposome particles (ALPs). No intracellular fluorescent signal was observed in the tumor cells treated with the unmodified calcein/ALPs and ICG/ALPs, whereas the surface modification with a cell-penetrating polyarginine peptide (R8 or R12) allows cellular uptake of the ALPs. The results demonstrate that the ALPs encapsulating small anionic drugs will be useful for target-specific delivery after modification of target-specific ligands.
목차
Abstract
Ⅰ. Introduction
Ⅱ. Experiment
Ⅲ. Results and Discussion
References
참고문헌 (15)
참고문헌 신청
[학술지(정기간행물)] - X. Xu / 2012 / / Int. J. Pharmceut 423 : 543 ~
[학술지(정기간행물)] - T. M. Allen / 2013 / / Adv. Drug. Deliv. Rev 65 : 36 ~
[학술지(정기간행물)] - J. Rautio / 2008 / / Nature Rev. Drug Discov 7 : 255 ~
[학술지(정기간행물)] - G. J. Charrois / 2004 / / Biochim. Biophys. Acta 1663 : 167 ~
[학술지(정기간행물)] - H. Maeda / 2000 / / T, J. Control. Release 65 : 271 ~
[학술지(정기간행물)] - T. M. Allen / 2013 / / Adv. Drug. Deliv. Rev 65 : 36 ~
[학술지(정기간행물)] - J. Rautio / 2008 / / Nature Rev. Drug Discov 7 : 255 ~
[학술지(정기간행물)] - G. J. Charrois / 2004 / / Biochim. Biophys. Acta 1663 : 167 ~
[학술지(정기간행물)] - H. Maeda / 2000 / / T, J. Control. Release 65 : 271 ~
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UCI(KEPA) : I410-ECN-0101-2019-420-001275784