지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.9
- 수록면
- 95 - 114 (20page)
이용수
초록· 키워드
오류제보하기
Increasing resistance due to the production of extended-spectrum β-lactamase (ESBL) in Escherichia coli is a major problem to public health and CTX-M enzymes have become the most prevalent ESBL worldwide. In this study, resistance profiles of E. coli isolated in Korea and the genetic environments of blaCTX-M genes were analyzed by PCR and direct sequencing to clarify the mechanisms of spread of CTX-M. Resistance rates of CTX-M-producing E. coli, including β-lactams, fluoroquinolones and aminoglycosides, were significantly higher than that of CTX-M-non-producers (p＜0.01). Of 41 tested, 39 (95.1%) isolates of CTX-M-producing E. coli showed resistance transfer by conjugation. All the transconjugants harboured large plasmids of 118~172 megadalton. Insertion sequence ISEcp1B was detected in the upstream of the blaCTX-M in 38 (92.7%) isolates with blaCTX-M. ISEcp1B was disrupted by IS26 in 16 (39.0%) isolates with blaCTX-M. ISEcp1B carried -35 and -10 promoter components between right inverted repeat (IRR) and the start codon of blaCTX-M. orf477 or IS903D was observed in the downstream of the blaCTX-M in all the isolates with blaCTX-M-3/15/55 or with blaCTX-M-14/27, respectively. Sequence similar to IRR of ISEcp1B was located downstream of orf477. Target duplication sequences were detected both upstream of IRL and downstream of IRR. These results showed the involvement of ISEcp1B in the mobilization of the resistance genes. In conclusion, the surrounding DNAs of blaCTX-M genes were very diverse, and the spread and the expression of CTX-M may be deeply related with ISEcp1B. These informations will provide important knowledge to control the increase in CTX-M-ESBLs.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
First Description of Shigella sonnei Harboring blaCTX-M-55 Outside Asia
Journal of Microbiology and Biotechnology
2016 .12
-
Characteristics of Transmissible CTX-M- and CMY-Type β-Lactamase- Producing Escherichia coli Isolates Collected from Pig and Chicken Farms in South Korea
Journal of Microbiology and Biotechnology
2017 .01
-
Complete Genome Sequence of an ESBL-producing Salmonella Infantis Strain IJCS5-22 that Harbors bla CTX-M-65 Isolated from Retail Chicken Meat in Korea
한국미생물·생명공학회지
2024 .09
-
충청지역에 위치한 일개의 대학병원에서 분리된 CTX-M-14형 ESBL 생성 대장균을 대상으로 PMQR 유전자 빈도조사
대한임상검사과학회지
2016 .01
-
Fecal Carriage of Antimicrobial-Resistant Enterobacteriaceae in Healthy Korean Adults
Journal of Microbiology and Biotechnology
2018 .01
-
Genetic Characteristics of Extended-Spectrum Beta-Lactamase-Producing Salmonella Isolated from Retail Meats in South Korea
Journal of Microbiology and Biotechnology
2024 .05
-
경북지역의 닭으로부터 CTX-M-14 생성 장내세균 분리동정
대한임상검사과학회지
2016 .01
-
The Occurrence of CTX-M–producing E. coli in the Broiler Parent Stock in Korea
한국미생물학회 학술대회논문집
2021 .08
-
Association Between Toxin-antitoxin Systems on Plasmids and Persister Formation in CTX-15-producing Klebsiella pneumoniae ST11 Isolates
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2019 .06
-
합성 유전자를 이용하여 Escherichia coli에서 백신 후보의 생산 혹은 진단용 항체의 개발을 위한 인간 rotavirus VP8* 부분 단백질의 발현
생명과학회지
2018 .04
-
CRISPR/Cas9-Mediated Re-Sensitization of Antibiotic-Resistant Escherichia coli Harboring Extended-Spectrum β-Lactamases
Journal of Microbiology and Biotechnology
2016 .01
-
Transfer of Antimicrobial-Resistant Escherichia coli and Resistance Genes in a Child Care Center
Journal of Microbiology and Biotechnology
2019 .01
-
Characterization of Pathogenic Escherichia coli Isolates from Food-borne Outbreaks in Gyeonggi-do, Korea
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2024 .06
-
Gene Knockdown of Essential Genes Using Artificial Small RNAs in Escherichia coli
한국미생물학회 학술대회논문집
2017 .04
-
Characteristic Study of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae (ESBL-PE) Isolated from Retail Meat in South Korea, 2021
한국미생물학회 학술대회논문집
2022 .10
-
Transcriptomic Profiles from Bdellovibrio bacteriovorus HD100 during Predation on an Extended-Spectrum Beta-Lactamase (ESBL) Strain of Escherichia coli
한국미생물학회 학술대회논문집
2016 .04
-
Prevalence of multidrug-resistant (MDR) Escherichia coli in untreated effluents from a wastewater treatment plant (WWTP) in Dhaka, Bangladesh
미생물학회지
2022 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0