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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.8
- 수록면
- 69 - 77 (9page)
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IL-18 is a crucial pro-inflammatory cytokine that mediates chronic intestinal inflammation. Metformin, an anti-diabetic drug, was reported to have ameliorative effects on inflammatory bowel disease. Recently, the mechanism of action of metformin was explained as a modulation of gut microbiota. In this study, fecal microbiota transplantation (FMT) using fecal material from metformin-treated mice was found to upregulate the expression of GLP-1 and pattern-recognition receptors TLR1 and TLR4 for the improvement in hyperglycemia caused by a high-fat diet. Further, FMT downregulated the expression of the inflammatory cytokine IL-18. Within the genera Akkermansia, Bacteroides, and Butyricimonas, which were promoted by metformin therapy, Butyricimonas was found to be consistently abundant following FMT. Our findings suggest that modulation of gut microbiota is a key factor for the anti-inflammatory effects of metformin which is used for the treatment of hyperglycemia.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (38)
참고문헌 신청
Harrison OJ / 2015 / Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine / Mucosal Immunol 8:1226~1236
Guan Q / 2017 / Recent advances: the imbalance of cytokines in the pathogenesis of inflammatory bowel disease / Mediators Inflamm 2017:4810258
Berstein LM / 2012 / Metformin in obesity, cancer and aging: addressing controversies / Aging (Albany NY) 4:320~329
Cameron AR / 2016 / Anti-inflammatory effects of metformin irrespective of diabetes status / Circ Res 119:652~665
Lee SY / 2015 / Metformin ameliorates inflammatory bowel disease by suppression of the STAT3 signaling pathway and regulation of the between Th17/Treg balance / PLoS One 10:e0135858
Guan Q / 2017 / Recent advances: the imbalance of cytokines in the pathogenesis of inflammatory bowel disease / Mediators Inflamm 2017:4810258
Berstein LM / 2012 / Metformin in obesity, cancer and aging: addressing controversies / Aging (Albany NY) 4:320~329
Cameron AR / 2016 / Anti-inflammatory effects of metformin irrespective of diabetes status / Circ Res 119:652~665
Lee SY / 2015 / Metformin ameliorates inflammatory bowel disease by suppression of the STAT3 signaling pathway and regulation of the between Th17/Treg balance / PLoS One 10:e0135858
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UCI(KEPA) : I410-ECN-0101-2019-517-001220096