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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.9
- 수록면
- 282 - 287 (6page)
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초록· 키워드
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Skin flap necrosis remains a major complication of reconstructive surgery. Euterpe oleracea Mart., popularly known as "acai berry" contains hydroxybenzoic acid, antioxidant polyphenolics and anthocyanins. These and other compounds within the acai berry confer anti-inflammatory and anti-oxidative effects. In this current study, we evaluated the protective effect of acai berry extracts on survival of random-pattern skin flaps in a murine model by histologic analysis. ICR mice were subjected to skin elevation surgery and orally administered acai berry extract (100 mg/kg) daily for 7 days. Tissues were stained with hematoxylin-eosin or Masson"s trichrome to observe tissue integrity and collagen deposition. In addition, TGF-β and VEGF was stained by immunofluorescence to determine anti-inflammatory cell infiltration and neovascularization, respectively. We found a decrease in inflammatory cell infiltration and increase in collagen deposition in the acai berry extract treated mice compared to control mice. Immunofluorescence staining reveal a higher number of TGF-β positive cells and enhanced VEGF staining in the acai berry extract treated mice. The results from this study indicate that oral uptake of acai berry extract can promote healing and survival of surgical skin flaps in mice providing an augmentative therapeutic approach to enhancing skin flap survival.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Atalay C / 2003 / Efficacy of topical nitroglycerin and transcutaneous electrical nerve stimulation on survival of random-pattern skin flaps in rats / Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery 37:10~13
Cassidy A / 2013 / High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women / Circulation 127:188~196
정건일 / 2013 / The Effects of Polydeoxyribonucleotide on the Survival of Random Pattern Skin Flaps in Rats / Archives of Plastic Surgery 40(3):181~186
Coelho da Mota DS / 2018 / Effects of acai and cilostazol on skin microcirculation and viability of tram flaps in hamsters / Journal of Surgical Research 228:253~262
Cuzzocrea S / 2000 / Effects of n-acetylcysteine in a rat model of ischemia and reperfusion injury / Cardiovascular Research 47:537~548
Cassidy A / 2013 / High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women / Circulation 127:188~196
정건일 / 2013 / The Effects of Polydeoxyribonucleotide on the Survival of Random Pattern Skin Flaps in Rats / Archives of Plastic Surgery 40(3):181~186
Coelho da Mota DS / 2018 / Effects of acai and cilostazol on skin microcirculation and viability of tram flaps in hamsters / Journal of Surgical Research 228:253~262
Cuzzocrea S / 2000 / Effects of n-acetylcysteine in a rat model of ischemia and reperfusion injury / Cardiovascular Research 47:537~548
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