메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한생화학·분자생물학회 Experimental and Molecular Medicine Experimental and Molecular Medicine 제49권
발행연도
2017.1
수록면
1 - 14 (14page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Tissue fibrosis, characterized by excessive accumulation of aberrant extracellular matrix (ECM) produced by myofibroblasts, is a growing cause of mortality worldwide. Understanding the factors that induce myofibroblastic differentiation is paramount to prevent or reverse the fibrogenic process. Integrin-mediated interaction between the ECM and cytoskeleton promotes myofibroblast differentiation. In the present study, we explored the significance of integrin alpha 11 (ITGA11), the integrin alpha subunit that selectively binds to type I collagen during tissue fibrosis in the liver, lungs and kidneys. We showed that ITGA11 was co-localized with α-smooth muscle actin-positive myofibroblasts and was correlatively induced with increasing fibrogenesis in mouse models and human fibrotic organs. Furthermore, transcriptome and protein expression analysis revealed that ITGA11 knockdown in hepatic stellate cells (liver-specific myofibroblasts) markedly reduced transforming growth factor β-induced differentiation and fibrotic parameters. Moreover, ITGA11 knockdown dramatically altered the myofibroblast phenotype, as indicated by the loss of protrusions, attenuated adhesion and migration, and impaired contractility of collagen I matrices. Furthermore, we demonstrated that ITGA11 was regulated by the hedgehog signaling pathway, and inhibition of the hedgehog pathway reduced ITGA11 expression and fibrotic parameters in human hepatic stellate cells in vitro, in liver fibrosis mouse model in vivo and in human liver slices ex vivo. Therefore, we speculated that ITGA11 might be involved in fibrogenic signaling and might act downstream of the hedgehog signaling pathway. These findings highlight the significance of the ITGA11 receptor as a highly promising therapeutic target in organ fibrosis.

목차

등록된 정보가 없습니다.

참고문헌 (1)

참고문헌 신청
Wynn TA / 2008 / Cellular and molecular mechanisms of fibrosis / J Pathol 214 : 199 ~ 210 | 2. [학술지(정기간행물)] - Desmouliere A / 2003 / Normal and pathologic soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis / Lab Invest 83 : 1689 ~ 1707 | 3. [학술지(정기간행물)] - Hinz B / 2012 / Recent developments in myofibroblast biology : paradigms for connective tissue remodeling / Am J Pathol 180 : 1340 ~ 1355 | 4. [학술지(정기간행물)] - Sugimoto H / 2006 / Identification of fibroblast heterogeneity in the tumor microenvironment / Cancer Biol Ther 5 : 1640 ~ 1646 | 5. [학술지(정기간행물)] - Wynn TA / 2011 / Integrating mechanisms of pulmonary fibrosis / J Exp Med 208 : 1339 ~ 1350 | 6. [학술지(정기간행물)] - Hinz B / 2007 / The myofibroblast: one function, multiple origins / Am J Pathol 170 : 1807 ~ 1816 | 7. [학술지(정기간행물)] - Humphreys BD / 2010 / Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis / Am J Pathol 176 : 85 ~ 97 | 8. [학술지(정기간행물)] - Kalluri R / 2003 / Epithelial-mesenchymal transition and its implications for fibrosis / J Clin Invest 112 : 1776 ~ 1784 | 9. [학술지(정기간행물)] - Thiery JP / 2009 / Epithelial-mesenchymal transitions in development and disease / Cell 139 : 871 ~ 890 | 10. [학술지(정기간행물)] - Piera-Velazquez S / 2011 / Role of endothelial-mesenchymal transition(EndoMT)in the pathogenesis of fibrotic disorders / Am J Pathol 179 : 1074 ~ 1080 | 11. [학술지(정기간행물)] - Friedman SL / 2008 / Mechanisms of hepatic fibrogenesis / Gastroenterology 134 : 1655 ~ 1669 | 12. [학술지(정기간행물)] - Gabbiani G / 2003 / The myofibroblast in wound healing and fibrocontractive diseases / J Pathol 200 : 500 ~ 503 | 13. [학술지(정기간행물)] - Gressner OA / 2007 / Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options / Comp Hepatol 6 : 7 ~ | 14. [학술지(정기간행물)] - Trautwein C / 2015 / Hepatic fibrosis:concept to treatment / J Hepatol 62 : S15 ~ S24 | 15. [학술지(정기간행물)] - Wynn TA / 2012 / Mechanisms of fibrosis : therapeutic translation for fibrotic disease / Nat Med 18 : 1028 ~ 1040 | 16. [학술지(정기간행물)] - Agarwal SK / 2014 / Integrins and cadherins as therapeutic targets in fibrosis / Front Pharmacol 5 : 131 ~ | 17. [학술지(정기간행물)] - Henderson NC / 2013 / Integrin-mediated regulation of TGFbeta in fibrosis / Biochim Biophys Acta 1832 : 891 ~ 896 | 18. [학술지(정기간행물)] - Humphries JD / 2006 / Integrin ligands at a glance / J Cell Sci 119 : 3901 ~ 3903 | 19. [학술지(정기간행물)] - Hynes RO. / 2002 / Integrins: bidirectional, allosteric signaling machines / Cell 110 : 673 ~ 687 | 20. [학술지(정기간행물)] - Henderson NC / 2013 / Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs / Nat Med 19 : 1617 ~ 1624 | 21. [학술지(정기간행물)] - Munger JS / 1999 / The integrin alpha v beta 6 binds and activates latent TGF beta 1 : a mechanism for regulating pulmonary inflammation and fibrosis / Cell 96 : 319 ~ 328 | 22. [학술지(정기간행물)] - Popova SN / 2007 / Physiology and pathology of collagen receptors / Acta Physiol(Oxf) 190 : 179 ~ 187 | 23. [학술지(정기간행물)] - Tiger CF / 2001 / α11β1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells / Dev Biol 237 : 116 ~ 129 | 24. [학술지(정기간행물)] - Popova SN / 2004 / The mesenchymal alpha11beta1 integrin attenuates PDGF-BBstimulated chemotaxis of embryonic fibroblasts on collagens / Dev Biol 270 : 427 ~ 442 | 25. [학술지(정기간행물)] - Talior-Volodarsky I / 2012 / α11integrin stimulates myofibroblast differentiation in diabetic cardiomyopathy / Cardiovasc Res 96 : 265 ~ 275 | 26. [학술지(정기간행물)] - Honda E / 2010 / Transforming growth factor-beta upregulates the expression of integrin and related proteins in MRC-5human myofibroblasts / Tohoku J Exp Med 220 : 319 ~ 327 | 27. [학술지(정기간행물)] - Lu N / 2010 / The human alpha11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta1 in a Smad-and Sp1-dependent manner / Matrix Biol 29 : 166 ~ 176 | 28. [학술지(정기간행물)] - Carracedo S / 2010 / The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation / J Biol Chem 285 : 10434 ~ 10445 | 29. [학술지(정기간행물)] - Navab R / 2016 / Integrin alpha11beta1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer / Oncogene 35 : 1899 ~ 1908 | 30. [학술지(정기간행물)] - Vaira V / 2010 / Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors / Proc Natl Acad Sci USA 107 : 8352 ~ 8356 | 31. [학술지(정기간행물)] - The French METAVIR Cooperative Study Group / 1994 / Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C / Hepatology 20 : 15 ~ 20 | 32. [학술지(정기간행물)] - Kramann R / 2015 / Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis / Cell Stem Cell 16 : 51 ~ 66 | 33. [학술지(정기간행물)] - Inagaki Y / 2007 / Emerging insights into transforming growth factor beta Smad signal in hepatic fibrogenesis / Gut 56 : 284 ~ 292 | 34. [학술지(정기간행물)] - Margadant C / 2010 / Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing / EMBO Rep 11 : 97 ~ 105 | 35. [학술지(정기간행물)] - Hu L / 2015 / An overview of hedgehog signaling in fibrosis / Mol Pharmacol 87 : 174 ~ 182 | 36. [학술지(정기간행물)] - Olinga P / 2013 / Precision-cut liver slices : a tool to model the liver ex vivo / J Hepatol 58 : 1252 ~ 1253 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0