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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한의진균학회 대한의진균학회지 대한의진균학회지 제15권 제2호
발행연도
2010.1
수록면
61 - 76 (16page)

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Background: Inflammatory response on LPS and IFN-γ induced Macrophage Raw 264.7 cells was secreted NO (nitric oxide) and PGE2 (prostaglandin E2) though expression of iNOS and COX-2. And many pro-inflammatory cytokines (TNF-α, IL-1β, IL-6 etc.) was secreted on LPS and IFN-γ induced Macrophage Raw 264.7 cells, too. Atopy dermatitis was inflammatory skin disease with pruritus,xeroderma and specific eczema. Objective: We sought to effect of anti-inflammation and skin hydration of AF-343 on Macrophage Raw 264.7 cells and NC/Nga mice with Atopic Dermatitis. Methods: The immune response of Raw 264.7 cells were induced by LPS and IFN-γ. Then LPS and IFN-γ induced Raw 264.7 cells was measured NO, PGE2 production after treatment of different concentrations for AF-343. The related genes (iNOS, COX-2) for NO, PGE2 production were detected using Western blot in LPS and IFN-γ induced Raw 264.7 cells after treatment of different concentrations for AF-343. Pro-inflammatory cytokines were detected, too. NC/Nga mice as Atopy dermatitis model was induced atopy dermatitis. Then NC/Nga mice with atopy dermatitis were performed oral administration of AF-343 for 1weeks. After oral administration of AF-343, TEWL was measured on skin tissues of NC/Nga mice with atopy dermatitis according to whether were performed oraladministration of AF-343 or not. And pro-inflammatory cytokines and IgE was measured in serum,protein of skin tissues of NC/Nga mice. Skin tissues of NC/Nga mice were performed H&E staining,immunohistochemical staining for PCNA, Involucrin and filaggrin. Results: LPS and IFN-γ induced Raw 264.7 cells was decreased NO, PGE2 production in dose-dependent after treatment of different concentrations for AF-343. The expression level of iNOS,COX-2 protein was decreased in dose-dependent, too. The related pro-inflammatory cytokines in media with LPS and IFN-γ induced Raw 264.7 cells were decreased after treatment of different concentrations for AF-343. TEWL level of NC/Nga mice skin (back, ear) with atopy dermatitis according to whether were performed oral administration of AF-343 or not was decreased in NC/Nga mice with atopy dermatitis group was performed oral administration by AF-343. When NC/Nga mice group with atopy dermatitis was performed oral administration by AF-343, induced pro-inflammatory cytokines and IgE expression in serum, protein of back, ear skin tissues of each NC/Nga mice group was decreased. H&E stained Skin tissues of NC/Nga mice was confirmed that thickness of epidermis, dermis were decreased in NC/Nga mice group with atopy dermatitis was performed oral administration by AF-343 than NC/Nga mice group with atopy dermatitis. The expression of PCNA, involucrin and filaggrin were decreased in NC/Nga mice group with atopy dermatitis was performed oral administration by AF-343than NC/Nga mice group with atopy dermatitis as results of immunihistochemical staining using specific antibodies such as PCNA as cell proliferation marker, involucrin and filaggrin as keratinocytes differentiation markers for skin tissues (back, ear) of NC/Nga mice. Conclusion: We confirmed effect of anti-inflammation and skin hydration of AF-343 on Macrophage Raw 264.7 cells and NC/Nga mice with Atopic Dermatitis. In conclusion, AF-343 is expecting as therapeutics for atopic dermatitis.
#Atopic dermatitis #Dandelion #AF-343 #Inflammation #Skin hydration

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참고문헌 (12)

참고문헌 신청
Bhattacharyya A / 2002 / Mitogen-activated protein kinases and NF-kappaB regulate pylori-mediated IL-8 release from macrophages / Biochem J 366 : 76 ~ 382 google schola Binetruy B / 1991 / Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain / Nature 351 : 122 ~ 127 google schola Blichmann CW / 1988 / Assessment of skin moisture. Measurement of electrical conductance, capacitance and transepidermal water loss / Acta Derm Venereol 68 : 284 ~ 290 google schola Dinarello CA / 2000 / Pro-inflammatory cytokine / Chest 11 : 503 ~ 508 google schola Jennifer H / 2002 / IFN-γ-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking / J. Immunol 168 : 3195 google schola

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