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자료유형
학술저널
저자정보
Kim, Tae Hong (Department of Environmental Materials Science, Institute of Agriculture & Life Science, Gyeongsang National University) Ha, Si Young (Department of Environmental Materials Science, Institute of Agriculture & Life Science, Gyeongsang National University) Yang, Jae-Kyung (Department of Environmental Materials Science, Institute of Agriculture & Life Science, Gyeongsang National University)
저널정보
한국목재공학회 목재공학(Journal of the Korean Wood Science and Technology) 목재공학 제42권 제5호
발행연도
2014.1
수록면
579 - 589 (11page)

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Atopic dermatitis (AD) syndrome is one of the most common and severe skin diseases in Korea; a large population has this disease. We examined the effects of the extract from the leaf and sprig of Camellia sinensis on the development of AD by using NC mice as a model of atopic dermatitis. Oral administration of the extract to NC/Nga mice treated with 2,4?dinitrochlorobenzene (DNCB) inhibited the development of AD-like skin lesions as shown by a significant decrease in the skin symptoms of the disease and a decrease in ear thickness and levels of immunoglobulin E (IgE) and thymus-and activation-regulated chemokine (TARC) level in the skin. Administration of the extract markedly suppressed the DNCB-induced mRNA expression of interleukin 4 (IL-4) and tumor necrosis factor ${\alpha}$ (TNF-${\alpha}$). The findings suggest that transdermal application of the extract may modulate in the skin of NC/Nga mice. The extract was effective for the prevention and treatment of AD.

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