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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 491 - 498 (8page)
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Copy-number variation(CNV) in particular genomic segments owing to deletions or duplications can induce changes in cellular gene expression patterns and may increase susceptibility to diseases such as cancer. The aim of this study was to examine CNVs related to the incidence of epithelial ovarian cancer in chickens. Genomic DNA was extracted from blood cells and cancerous ovaries collected from four 120-week-old White Leghorn chickens and were used for array-based comparative genome hybridization(CGH) analysis. As a result, 25 amplified and 10 deleted CNV regions were detected in chicken ovarian cancer. Of these, 10 amplified and two deleted CNV regions contained genes associated with human ovarian cancer. Our study using a chicken model may provide a better understanding of human epithelial ovarian cancer.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Abeysinghe, H. R. / 2003 / THY1 expression is associated with tumor suppression of human ovarian cancer / Cancer Genet Cytogenet 143 (2) : 125 ~ 132
Ahn, S. E. / 2010 / Increased expression of cysteine cathepsins in ovarian tissue from chickens with ovarian cancer / Reprod Biol Endocrinol. 8 : 100 ~
Dimova, I. / 2009 / Genomic markers for ovarian cancer at chromosomes 1, 8 and 17 revealed by array CGH analysis / Tumori 95 (3) : 357 ~ 366
Feuk, L. / 2006 / Structural variation in the human genome / Nat Rev Genet 7 (2) : 85 ~ 97
Fredrickson, T. N. / 1987 / Ovarian tumors of the hen / Environ Health Perspect 73 : 35 ~ 51
Ahn, S. E. / 2010 / Increased expression of cysteine cathepsins in ovarian tissue from chickens with ovarian cancer / Reprod Biol Endocrinol. 8 : 100 ~
Dimova, I. / 2009 / Genomic markers for ovarian cancer at chromosomes 1, 8 and 17 revealed by array CGH analysis / Tumori 95 (3) : 357 ~ 366
Feuk, L. / 2006 / Structural variation in the human genome / Nat Rev Genet 7 (2) : 85 ~ 97
Fredrickson, T. N. / 1987 / Ovarian tumors of the hen / Environ Health Perspect 73 : 35 ~ 51
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