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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Cervical cancer is associated with low antioxidant status. It has a high prevalence especially amongst woman in Asia and is a leading cause of cancer death. Cancer chemotherapy in vivo improved in cases with high p53 expression in the tumor tissue. The restoration of p53 levels could be a potential strategy to increase chemoresponsiveness. Under circumstances where damage is extensive, p53 plays a direct role in trigering apoptosis. To investigate the effect of curcumin (CMN) as an antioxidant agent on anticancer agent 5-fluorouracil (5FU) induced apoptosis and p53 expression, HPV-18positive HeLa cells were treated with noncytotoxic amounts of antioxidant. Curcumin induced apoptosis in cervical cancer cells. Morphological hallmarks of apoptosis such as nuclear fragmentation and internucleosomal fragmentation of DNA were observed. CMN caused upregulation of p53 expression, evident from Western blotting data and also increased the susceptibility/apoptosis induced by 5FU. These results show that increasing drug sensitivity of cervical cancer cells by upregulation of p53 using CMN is novel approach and could have a possible therapeutic potential in cervical cancer.
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참고문헌 (22)
참고문헌 신청
Bisht S / 2007 / Polymeric nanoparticle-encapsulated curcumin (“nanocurcumin”): a novel strategy for human cancer therapy / J Nanobiotechnol 5 : 3 ~ 20
Candelaria M / 2006 / Radiosensitizers in cervical cancer: cisplatin and beyond / Radiat Oncol 1 : 15 ~
Chen GQ / 1996 / In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell ap
Chen H / 1999 / Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma cells / Anticancer Res 19 : 3675 ~ 3680
Choudhuri T / 2002 / Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction / FEBS Letters 512 : 334 ~ 340
Candelaria M / 2006 / Radiosensitizers in cervical cancer: cisplatin and beyond / Radiat Oncol 1 : 15 ~
Chen GQ / 1996 / In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell ap
Chen H / 1999 / Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma cells / Anticancer Res 19 : 3675 ~ 3680
Choudhuri T / 2002 / Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction / FEBS Letters 512 : 334 ~ 340
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