지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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In this study morphological changes of the testes of golden hamsters treated with 6-aminonicotinamide (6-AN, 10 mg/
kg body weight) in every two days were investigated using light and transmission electron microscopes.
After the 7th injection of 6-AN, body weights of hamsters were significantly reduced, and the weight of testes were
markedly reduced in the group of hamsters after 5th injections.
Degeneration of seminiferous epithelium appeared first in the group receiving 5th injections, which were followed by
severe degenerations after the 9th injection. In the degenerated seminiferous epithelium, deep vacuolization, and destruction
of spermatogenic cells and Sertoli cells were also oberved. Multinuclear giant cells were also observed in the lumen
of destructed seminiferous epithelium. But there were no edematous changes in the interstitial tissue, and the Leydig cells
were found to be relatively intact. Therefore, these results show that 6-AN trigger severe morphological alteration of the
spermatogenic cells and Sertoli cells, however Leydig cells are unaltered by 6-AN.
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참고문헌 (22)
참고문헌 신청
Aikawa H / 1986 / Lesions in the skin, intestine and central nervous system induced by an antimetabolite of niacin / Am J Pathol 122 : 335 ~ 342
Bakalska M / 2001 / Degeneration and restoration of spermatogenesis in relation to the changes in Leydig cell population following ethane dimethanesulfonate treatment in adul
Bolin DC / 1996 / The effect of 6-aminonicotinamide on testicular development in the rat / Vet Human Toxicol 38 (2) : 85 ~ 88
Desphande SS / 1978 / Physiological, biochemical and histological changes in skeletal muscles, neuromuscular junction and spinal cord of rats rendered paraplegic by administr
Formiglin L / 1986 / Thallium-induced testicular toxicity in the rat / Environm Res 40 : 531 ~ 539
Bakalska M / 2001 / Degeneration and restoration of spermatogenesis in relation to the changes in Leydig cell population following ethane dimethanesulfonate treatment in adul
Bolin DC / 1996 / The effect of 6-aminonicotinamide on testicular development in the rat / Vet Human Toxicol 38 (2) : 85 ~ 88
Desphande SS / 1978 / Physiological, biochemical and histological changes in skeletal muscles, neuromuscular junction and spinal cord of rats rendered paraplegic by administr
Formiglin L / 1986 / Thallium-induced testicular toxicity in the rat / Environm Res 40 : 531 ~ 539
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