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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The aims of the study were to establish a short-term screening test for detecting testicular toxicity of chemicals in rats and to determine whether a 2-week administration period is sufficient to detect testicular toxicity of 2-bromopropane (2-BP) as an example. Male Sprague-Dawley rats were subcutaneously administered with 1000 mg/kg/day of 2-BP or its vehicle for 2 weeks. Ten male rats each were sacrificed on days 3, 7 and 14 after the initiation of treatment. Parameters of testicular toxicity included genital organ weights, testicular sperm head counts, epididymal sperm counts, motility and morphology, and qualitative and quantitative histopathologic examinations. The early histopathological changes observed on day 3 of treatment included degeneration of spermatogonia and spermatocytes, multinuclear giant cells, mature spermatid retention, vacuolization of Sertoli cells, and decreased number of spermatogonia in stages Ⅱ and V. On day 7 of treatment, atrophy of seminiferous tubules, exfoliation of germ cells, degeneration of spermatogonia and spermatocytes, multinuclear giant cells, mature spermatid retention, vacuolization of Sertoli cells, decreased number of spermatogonia in stages Ⅱ and Ⅴ, and decreased number of spermatocytes in stages Ⅶ and XII. On day 14 after treatment, a significant decrease in the weights of testes and seminal vesicles was found. Atrophy of seminiferous tubules, exfoliation of germ cells, degeneration of spermatogonia and spermatocytes, mature spermatid retention, vacuolization of Sertoli cells, decreased number of spermatogonia in stages Ⅱ and Ⅴ, and decreased number of spermatocytes in all spermatogenic stages were also observed. In addition, a slight non-significant decrease in testicular sperm head counts, daily sperm production rate and epididymal sperm counts was found. The results showed that 2 weeks of treatment is sufficient to detect the adverse effects of 2-BP on male reproductive organs. It is considered that the short-term testicular toxicity study established in this study can be a useful tool for screening the testicular toxic potential of new drug candidates in rats.
목차
Abstract
재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (29)
참고문헌 신청
Bailey, S. A., R. H. Zidell and R. W. Perry. 2004. Relationships between organ weight and body/brain weight in the rat: what is the best analytical endpoint? Toxicol. Pathol. 32, 448-466.
Boekelheide, K., S. P. Darney, G. P. Daston, R. M. David, U. Luderer, A. F. Olshan, W. T. Sanderson, C. C. Willhite and S. Woskie. 2004. NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of 2-bromopropane. Reprod. Toxicol. 18, 1
Chung, M. K., S. J. Lee, Y. B. Kim, S. C. Park, D. H. Shin, S. H. Kim and J. C. Kim. 2005. Evaluation of spermatogenesis and fertility in F1 male rats after in utero and neonatal exposure to extremely low frequency electromagnetic fields. Asian J. Androl.
Chung, Y. H., J. H. Han and I. J. Yu. 2001. Reproductive toxicity assessment on 2-bromopropane using spermatogenesis stage classification and Sertoli cell indices. J. Toxicol. Pub. Health. 17, 267-272.
Chung, M. K. and J. C. Kim. 2000. Principles and methods for the reproductive-toxicological evaluation of new drug candidates. J. Toxicol. Pub. Health 16, 229-238.
Boekelheide, K., S. P. Darney, G. P. Daston, R. M. David, U. Luderer, A. F. Olshan, W. T. Sanderson, C. C. Willhite and S. Woskie. 2004. NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of 2-bromopropane. Reprod. Toxicol. 18, 1
Chung, M. K., S. J. Lee, Y. B. Kim, S. C. Park, D. H. Shin, S. H. Kim and J. C. Kim. 2005. Evaluation of spermatogenesis and fertility in F1 male rats after in utero and neonatal exposure to extremely low frequency electromagnetic fields. Asian J. Androl.
Chung, Y. H., J. H. Han and I. J. Yu. 2001. Reproductive toxicity assessment on 2-bromopropane using spermatogenesis stage classification and Sertoli cell indices. J. Toxicol. Pub. Health. 17, 267-272.
Chung, M. K. and J. C. Kim. 2000. Principles and methods for the reproductive-toxicological evaluation of new drug candidates. J. Toxicol. Pub. Health 16, 229-238.
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UCI(KEPA) : I410-ECN-0101-2009-470-015375067